ORIGINAL RESEARCH article
Front. Physiol.
Sec. Exercise Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1614942
miRNAs involved in the regulation of exercise fatigue
Provisionally accepted
- 1Sungshin Women's University, Seongbuk District, Republic of Korea
- 2Zhengzhou University, Zhengzhou, China
- 3School of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan Province, China
- 4Kookmin University, Seoul, Republic of Korea
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Exercise-induced fatigue refers to a temporary decline in physiological function resulting from prolonged or high-intensity exercise, which is characterized by decreased muscle strength, diminished exercise performance, and heightened subjective feelings of fatigue. T The study of exercise fatigue holds significant importance not only in competitive sports and public health, but also extends to medicine, military applications, and occupational safety. MicroRNA (miRNA) represents a class of non-coding RNA that plays a pivotal role in the regulation of gene expression. The involvement of miRNAs in exercise-induced fatigue has garnered increasing attention within the scientific community. This article provides an overview of fundamental concepts and biological functions associated with miRNAs, defines and classifies exercise fatigue while outlining its physiological changes, emphasizes alterations in miRNA expression during episodes of exerciseinduced fatigue, and conducts an in-depth analysis regarding the mechanisms through which miRNAs influence this phenomenon via modulation of energy metabolism, inflammatory responses, and oxidative stress.Furthermore, this article anticipates future research directions as well as potential clinical applications for miRNAs concerning exercise-induced fatigue. This review holds significant importance for elucidating the molecular mechanisms underlying exercise-related fatigue while fostering advancements within sports medicine and rehabilitation science.
Keywords: Exercise fatigue, microRNA, Energy Metabolism, Inflammatory Response, Oxidative Stress
Received: 20 Apr 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Niu, Yin, Cao, Huang, Deng and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhongyuan Deng, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, 450001, Henan Province, China
Jie Cao, Kookmin University, Seoul, 136-702, Republic of Korea
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