REVIEW article
Front. Physiol.
Sec. Integrative Physiology
This article is part of the Research TopicIntegrative Approaches to Acute Brain Injury: Vascular, Electrical, and Metabolic InteractionsView all 14 articles
Beyond Vascular Recanalization: Precision Medicine in Cervical Artery Dissection Guided by Multiple mechanisms and Multimodal Imaging for Brain Functional Recovery
Provisionally accepted
- 1Department of Radiology, First Hospital of Jilin University, Changchun, China
- 2Department of Otorhinolaryngology, The First Hospital of Jilin University, Changchun, China
- 3Department of Endocrinology, The First Hospital of Jilin University, Changchun, China
- 4Department of Breast Surgery, The First Hospital of Jilin University, Changchun, China
- 5Department of Neurology, The First Hospital of Jilin University, Changchun, China
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Cervical artery dissection (CAD), a critical etiological contributor of stroke in young adults, exerts direct influence on neurological prognosis through its vascular recanalization outcomes. However, pathological heterogeneity and ongoing controversies surrounding treatment strategies hinder the optimization of clinical decision-making; its prognosis is often not favorable. At present, there are a relative paucity of studies on recanalization of CAD. This review provides a concise overview of the pathological mechanisms and clinical challenges associated with CAD, along with recent advancements in advanced imaging modalities and clinico-anatomical classification systems. Furthermore, we critically evaluate current therapeutic paradigms and factors influencing recanalization while elucidating potential biological mechanisms underlying vascular restoration. A systematic analysis of translational utility in animal models is presented. Finally, based on the latest research progress in CAD and vessel recanalization, prospects are outlined aiming to establish a theoretical foundation for developing personalized and precise therapeutic approaches targeting CAD recanalization from multidimensional perspectives, and to offer reference for subsequent research.
Keywords: Cervical artery dissection, Endovascular Therapy, Hemodynamics, high-resolution MRI, ischemic stroke, pathomechanisms, precision medicine, recanalization
Received: 30 Aug 2025; Accepted: 19 Dec 2025.
Copyright: © 2025 Li, Gu, Dai, Tian, Zhang, Yin, Guo and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhenni Guo
Hongwei Zhou
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