ORIGINAL RESEARCH article
Front. Physiol.
Sec. Cardiac Electrophysiology
This article is part of the Research TopicExercise Prescription, Physiological Mechanisms, and Exercise Safety in Patients with Cardiac Devices and ArrhythmiasView all 6 articles
Asmeton minimizes dry cough and diaphragmatic contraction during pulsed-field ablation of atrial fibrillation: A clinical prospective randomized study
Provisionally accepted
Hui xing Liu
Yan ZhangHuafen LiuCan LengGangjie XieJiahao ZhaoJinlin HuangLei HuangWei LiuYuzhi LuHongwei Zhang
Songyun Wang*
Hong Jiang*- Renmin Hospital of Wuhan University, Wuhan, China
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Purpose: Pulsed field ablation (PFA) is a promising novel ablation modality for atrial fibrillation therapy. However, PFA might lead to dry cough and diaphragmatic contraction, especially under conscious sedation. We aim to explore a novel approach to reduce dry cough and diaphragmatic contraction during PFA procedures under conscious sedation. Methods: Sixteen patients underwent PFA pulmonary vein isolation under conscious sedation were divided into the Asmeton group (with preprocedure Asmeton) and the Control group. A scoring system was developed to assess dry cough and diaphragmatic contraction. Results: A total of 608 ablations and 893 ablations were performed in the Control and Asmeton group, respectively. The dry cough score (P = 0.045) in all pulmonary veins was significantly reduced by 73.1% in the Asmeton group in comparison with the Control group. The proportion of medium to high dry cough decreased from 12.2 ± 10.4% in the Control group to 1.8 ± 3.7% in the Asmeton group (P = 0.027). The diaphragmatic contraction score in the Asmeton group was 37.5% lower than that in the Control group, the proportion of severe diaphragmatic contraction was significantly reduced from 2.8 ± 8.4% in the Control group to 0.0 ± 0.0% in the Asmeton group (P = 0.006). Conclusion: Asmeton might eliminate moderate to severe dry cough and reduce the severity of diaphragmatic contraction during pulmonary vein isolation under conscious sedation ablation.
Keywords: Asmeton, Atrial Fibrillation, diaphragmatic contraction, Dry cough, pulsed-field ablation
Received: 09 Sep 2025; Accepted: 30 Dec 2025.
Copyright: © 2025 Liu, Zhang, Liu, Leng, Xie, Zhao, Huang, Huang, Liu, Lu, Zhang, Wang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Songyun Wang
Hong Jiang
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