REVIEW article
Front. Physiol.
Sec. Lipid and Fatty Acid Research
Alterations in lipid metabolism and blood profile in gynecological cancers – potential strategies in diagnosis and treatment
Provisionally accepted
Yelyzaveta Razghonova
Anna Abacjew-ChmyłkoMonika CzapiewskaDariusz WydraJulian Swierczynski
Adriana Maria Mika
Tomasz Sledzinski*- Medical University of Gdansk, Gdańsk, Poland
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Gуnеcоlоgіcal cancers (GCs), especially еndоmеtrіal, cervical and оvarіan cancеrs, represent a major health burden due to their increasing incidence and poor treatment outcomes, particularly in advanced stages. Numerous papers suggest that reprogramming of lipid metabolism plays an important role in the development and progression of GCs. In this review, we discuss the alterations in lipid metabolism, focusing on a) serum/plasma lіpіd prоfіlеs and changes in membrane lipid composition in GCs patients, b) dysregulation of fatty acid uptakе and β-oxidation by GCs cells, and c) upregulation of lipogenic enzymes in cancer tissue of GCs patients and GCs cells lines. It appears that lipid alterations in the development and progression of GCs are very complex and cancer type specific. This is due to the complexity of a) the structure and properties of lipids, b) the variability between different human cancer types, and c) the need for a comprehensive set of clinical data. Moreover, the review highlights alterations of lipid metabolism as potential diagnostic and therapeutic strategies in the treatment of GC patients. Further studies are still needed to draw clear conclusions about the relationship between abnormalities in lipid metabolism and development of GCs and to bridge basic research and practice.
Keywords: cervical cancer5, Endometrial cancer3, fatty acids1, lipogenic enzymes2, ovarian cancer4
Received: 07 Nov 2025; Accepted: 02 Jan 2026.
Copyright: © 2026 Razghonova, Abacjew-Chmyłko, Czapiewska, Wydra, Swierczynski, Mika and Sledzinski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tomasz Sledzinski
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