REVIEW article
Front. Physiol.
Sec. Mitochondrial Research
The Interaction between Sarcoplasmic Reticulum and Mitochondria: a Novel Mechanism for Cardiac Arrhythmia
Zhongyang Yu 1
Meng Zhao 2
Hongyue Xu 2
Ji Sun 1
Xiaoxing Jin 1
1. Tongji Hospital Affiliated to Tongji University, Shanghai, China
2. Jilin University, Changchun, China
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Abstract
Cardiovascular diseases are a major cause of morbidity and mortality worldwide. Cardiac arrhythmias, especially fatal ventricular arrhythmias, are highly harmful to patients and can even lead to sudden death. While electrical and structural remodeling of myocardial tissue represent the mainstream mechanisms underlying arrhythmogenesis, there is a critical need to explore novel perspectives. This review focuses on the communication between the sarcoplasmic reticulum (SR) and mitochondria as an independent mechanistic lens. We detail how this specific interaction governs Ca²⁺ transfer and cell-death signaling, positioning it as a potentially pivotal, distinct pathway that contributes to and amplifies the development of cardiac arrhythmias.
Summary
Keywords
a Novel Mechanism, cardiac arrhythmia, Mitochondria, Sarcoplasmic Reticulum, SR-mitochondria interaction
Received
29 December 2025
Accepted
16 February 2026
Copyright
© 2026 Yu, Zhao, Xu, Sun and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Zhongyang Yu; Ji Sun; Xiaoxing Jin
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.