REVIEW article
Front. Radiol.
Sec. Neuroradiology
Volume 5 - 2025 | doi: 10.3389/fradi.2025.1605777
Imaging Hallmarks of Idiopathic Intracranial Hypertension and Insights into Pathogenesis
Provisionally accepted
- Thomas Jefferson University, Philadelphia, United States
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Idiopathic Intracranial hypertension (IIH), also referred to as pseudotumor cerebri, is a term used to describe increased intracranial pressure in the absence of a known identifiable secondary cause. Despite advancements of neuroimaging techniques, imaging of the pathological underpinnings in the diagnosis of IIH has been limited. Although the causation of IIH has been ascribed to increased Cerebrospinal Fluid production and disordered drainage through the dural sinuses, new evidence shows that the glymphatic system which is an alternate pathway of drainage is likely to play a pivotal role. In this review, we address the pathophysiological underpinnings in the causation of IIH and discusses characteristic anatomical imaging findings on conventional MRI and explore the role of advanced imaging techniques.
Keywords: Idiopathic Intracranial Hypertension, Glymphatic system, Magnetic resonance, diffusion tensor image analysis along the perivascular space, Intracranial Pressure
Received: 03 Apr 2025; Accepted: 05 May 2025.
Copyright: © 2025 Basimah, Faro, Yuan, Talekar, Mondel, Qiu and Chaganti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: joga Chaganti, Thomas Jefferson University, Philadelphia, United States
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