MINI REVIEW article
Front. RNA Res.
Sec. Non-coding RNA
Volume 3 - 2025 | doi: 10.3389/frnar.2025.1679653
This article is part of the Research TopicCurrent Insights in RNA ResearchView all articles
Y RNA and Y RNA-derived ysRNAs associations with viral pathogens
Provisionally accepted
- University of South Alabama, Mobile, United States
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Y RNAs are a poorly-studied class of small non-coding RNAs (sncRNAs) which have previously been implicated in the pathogenesis of different human diseases, including cardiac and autoimmune conditions, as well as certain cancers. In recent years, however, multiple studies have reported correlations between Y RNA expressions and disease outcomes in viral infections (e.g., IAV, HIV, HPV, and SARS-CoV-2) as well as potential mechanistic roles that Y RNAs may play in host anti-viral defense. These studies suggest that Y RNAs may be associated with upregulation of viral defense proteins as well as altered cell-cell communication during viral infections. In this review, current literature detailing Y RNA effects on human viral infection will be summarized and future directions in the study of these relationships discussed.
Keywords: Y RNA, ysRNA, microRNA, virus, SARS-CoV-2, HIV, Influenza A virus, innate immunity
Received: 04 Aug 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Olliff, Mabien, Cole and Borchert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Glen Mark Borchert, University of South Alabama, Mobile, United States
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