Medical staff treating a patient with sepsis

Solving sepsis using systems immunology

A precision medicine strategy to decode, diagnose, and treat sepsis

Sepsis, a complex and heterogenous syndrome triggered by infection, causes millions of deaths each year through multi-organ dysfunction and failure. Could systems immunology yield precision medicine solutions to this hidden global health crisis?

Hancock et al. demonstrate how bioinformatic analysis of gene expression and other omics data could reshape sepsis care through early detection, patient endotyping, and individualized, stage-specific therapies. Their lead article—and accompanying hub publications—explore how systems immunology approaches to improve sepsis outcomes could also yield insights into severe COVID-19 and inform pathogen-agnostic strategies for future pandemic preparedness.

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