CASE REPORT article
Front. Transplant.
Sec. Abdominal Transplantation
Volume 4 - 2025 | doi: 10.3389/frtra.2025.1500066
Persistent Drug-Resistant Pseudomonas aeruginosa infection in a young postkidney transplant patient that proved fatal
Provisionally accepted
Supreeta Shettar1
Sumana Mahadevaiah1*
Manjunath S Shetty2
Yogeesh D Maheshwarappa1*
Raghukanth Reddy2
Asha Srinivasan3
Vamshi Dharan2
Gautam Kalyatanda4
G K Megha1- 1Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
- 2Dept of Nephrology, JSS Medical College and Hospital, JSS AHER,, Mysuru, India
- 3Division of Nanoscience and Technology, School of Life Sciences, JSS AHER, Mysuru, India
- 4Division of Infectious Diseases & Global Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States
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This case report highlights the management of recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Pseudomonas aeruginosa in a post-renal transplant patient. Despite the challenges posed by antibiotic resistance, the patient was successfully treated with an extended infusion of meropenem, underscoring the efficacy of this approach in such difficult cases. The patient's recurrent infections required multiple hospitalizations and adjustments in treatment protocols, including the use of alternative antibiotics like fosfomycin and tailored immunosuppressive management to control both infection and rejection. This case is noteworthy for demonstrating the successful management of recurrent UTIs in the immunocompromised patient population, providing valuable insights into the treatment strategies that can be employed in similar clinical scenarios.
Keywords: Pseudomonas aeruginosa, Urinary tract infection, immunocompromised conditions, Multidrug resistant organism (MDRO), Recurrent hospitalization, Recurrent UTIs
Received: 22 Sep 2024; Accepted: 23 Jun 2025.
Copyright: © 2025 Shettar, Mahadevaiah, Shetty, Maheshwarappa, Reddy, Srinivasan, Dharan, Kalyatanda and Megha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sumana Mahadevaiah, Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
Yogeesh D Maheshwarappa, Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
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