About this Research Topic
Animal models, including yeast, C. elegans, mice, rats and more recently, dogs, have helped establish the foundational hallmarks of aging. Seminal discoveries, including the role of insulin signaling in lifespan extension, as well as the effects of key anti-geronic interventions like rapamycin and caloric restriction have been validated through this evolutionary scale. Recent advances using new animal models (killiefish, marmosets, etc) have challenged some of these findings, and opened up exciting new avenues to understand the biochemical and organismal pathways that underlie aging. In this Research Topic, we will focus on the comparative biology of model organisms in aging research, and we welcome new research manuscripts or reviews manuscripts highlighting the contributions of metabolism, proteostasis and redox biology to the process of aging.
One of the goals of this issue is to highlight the abundance of stellar junior faculty and rising stars in the field of aging research, and for them to take advantage of the fast, peer-review system already in place at Frontiers at key junctions in their careers. We also highly encourage women and minorities underrepresented in research to submit.
Keywords: rapamycin, caloric restriction, comparative biology, metabolism, redox biology, proteostasis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.