Mechanistic Insights in Hereditary Kidney Disease

Increased accessibility to genetic testing as a diagnostic approach for heritable renal conditions has considerably expanded our knowledge of kidney disease. As a consequence, appreciation for the genetic nature of multiple renal diseases has grown, leading to the emergence of new mechanistic insights into renal disease pathogenesis. Thanks to increasingly sophisticated diagnostic approaches and novel animal models of suspected heritable diseases, the field is poised for advances in patient care and therapeutic strategies based upon these mechanistic insights.

Frontiers in Nephrology is organizing a special collection of articles (reviews and original research) focused on Mechanistic Insights in Hereditary Kidney Disease. As our understanding of renal disease heritability and the genetic variation underlying these conditions is updated frequently, investigation of novel mechanisms that can lead to informed approaches is essential. This Research Topic aims at highlighting cutting edge work that seeks to uncover the role of genetics and heritability in renal disease and expand our current understanding of the underlying mechanisms of pathogenesis.

Sub-themes for this Research Topic may include, but are not limited to:

- Animal Models of Hereditary Kidney Disease

- Insights into Renal Disease Mechanisms from Genetic Differences

- New Mechanistic Insights into Genetic Renal Disease

- Signaling Pathway Dysfunction in Hereditary Kidney Disease

Keywords: nephrology, genetics, pathogenesis, diagnosis, disease mechanism

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.