About this Research Topic
Coronary cardiovascular disease is the leading cause of heart attack, stroke and even death worldwide; a positive correlation of severity of heart disease with the extend of hardening of arteries, which is caused in part by faulty endothelial cells, smooth muscle cells, and immune cells accentuates the imperativeness of understanding how these various cell types contribute to promoting the disease development and progression. How to preclude healthy cardiovascular system from damage and insult is a long-standing but highly medically relevant question.
In current Research Topic, we seek to publish a new high-impact article collection of investigations on the function of various cell types including smooth muscle cell, stem cell, endothelial cell, immune cell, and other cell types involved in vascular and metabolic physiology, and regulating vascular heterogeneity, cell-cell communication, inflammation, signaling and regeneration. We welcome contributions from diverse fields of studying lymphatics, lymphangiogenesis, angiogenesis, vascular remodeling, neurovascular crosstalk, smooth muscle cell differentiation and plasticity, atherosclerosis, heart failure, mechanotransduction, and lipid metabolism by employing cutting-edge technologies and innovative methodologies such as scRNA-Seq, multiomics, and CRISPR/Cas9-mediated gene editing to investigate in-depth molecular mechanisms. Ultimately, we are in hopes of bringing forward new approaches to treat cardiovascular disorders and to reduce the burdens of human heart disease.
We are interested in a new high-impact article collection of articles comprising of original research, insightful review, news and views, and case reports, elucidating the function of various cell types including smooth muscle cell, stem cell, endothelial cell, immune cell, and other cell types involved in vascular and metabolic physiology, and regulating vascular heterogeneity, cell-cell communication, inflammation, signaling and regeneration.
Keywords: Smooth Muscle Cell, Stem Cell, Endothelial Cell, Immune Cell, Heterogeneity, Cell-cell interaction, Regenerative Medicine, Omics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.