Aging and Small Molecules: Mechanisms and Molecular Signaling Controlling Aging Phenotype

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ORIGINAL RESEARCH

Accepted on 30 May 2025

Regulation of Enzymes of De Novo Lipid Metabolism by Chaperone-Mediated Autophagy: Effects of the Lifespan-Extending MEK1 Inhibitor Trametinib

Jiexian Chen
Josh Berg
Calvin M Burns
Hanyi Jia
Xinna Li
Richard A Miller
S. Joseph Endicott
Gonzalo Garcia

doi 10.3389/fragi.2025.1621808

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BRIEF RESEARCH REPORT

Published on 17 Dec 2024

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

Gautham Yepuri
Kushie Kancharla
Riccardo Perfetti
Shoshana Shendelman
Andrew Wasmuth
Ravichandran Ramasamy

doi 10.3389/fragi.2024.1466281

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