Aging and Small Molecules: Mechanisms and Molecular Signaling Controlling Aging Phenotype

430
Total downloads
3,120
Total views and downloads

Articles

ORIGINAL RESEARCH

Published on 25 Jun 2025

The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy

Jiexian Chen
Joshua Berg
Calvin M. Burns
Hanyi Jia
Xinna Li
Richard A. Miller
S. Joseph Endicott
Gonzalo Garcia

doi 10.3389/fragi.2025.1621808

545 views

BRIEF RESEARCH REPORT

Published on 17 Dec 2024

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

Gautham Yepuri
Kushie Kancharla
Riccardo Perfetti
Shoshana Shendelman
Andrew Wasmuth
Ravichandran Ramasamy

doi 10.3389/fragi.2024.1466281

1,120 views

Share on

Frontiers in Aging

Frontiers in Aging

Interventions in Aging

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

3,120Topic views
1,589Article views
430Article downloads