Aging and Small Molecules: Mechanisms and Molecular Signaling Controlling Aging Phenotype

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ORIGINAL RESEARCH

Published on 25 Jun 2025

The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy

Jiexian Chen
Joshua Berg
Calvin M. Burns
Hanyi Jia
Xinna Li
Richard A. Miller
S. Joseph Endicott
Gonzalo Garcia

doi 10.3389/fragi.2025.1621808

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BRIEF RESEARCH REPORT

Published on 17 Dec 2024

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

Gautham Yepuri
Kushie Kancharla
Riccardo Perfetti
Shoshana Shendelman
Andrew Wasmuth
Ravichandran Ramasamy

doi 10.3389/fragi.2024.1466281

1,323 views

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Frontiers in Aging

Interventions in Aging

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