Insights in Molecular Mechanisms of Aging 2023/2024

About this Research Topic

Background

This Research Topic follows on from the previous 2022 entry in this series.

The field of molecular mechanisms of aging has seen remarkable progress, particularly in the last few years, as scientists have made significant strides in understanding the biological processes that underpin aging. Despite these advancements, the field continues to grapple with several pressing questions, such as the precise molecular pathways that drive aging and how these pathways can be modulated to promote healthy aging. Recent studies have highlighted the role of chromosomes, proteostasis, and nutrient sensing in aging, offering new insights into how these mechanisms contribute to cellular senescence and organismal aging. However, there remains a need for a more comprehensive understanding of these processes, as well as the development of novel interventions to mitigate age-related decline. Current research is addressing these gaps by exploring the intricate interplay between genetic, environmental, and lifestyle factors in aging, yet challenges persist in translating these findings into practical applications.

This research topic aims to illuminate the progress made in the molecular mechanisms of aging over the past decade and to identify future challenges that need to be addressed. By providing a comprehensive overview of the field, this collection seeks to inspire and guide researchers, encouraging them to explore new avenues and tackle the most pressing issues in aging research. Key objectives include understanding the essential mechanisms of aging, exploring the link between aging and COVID-19, and investigating the molecular underpinnings of aging-related syndromes such as osteosarcopenia.

To gather further insights in the molecular mechanisms of aging, we welcome articles addressing, but not limited to, the following themes:

- Chromosomal dynamics and their role in aging
- Proteostasis and its impact on cellular function
- Nutrient sensing and fuel selection in aging
- Lipid signaling and its mediators in aging processes
- Stem cell function and its decline with age
- Identification and validation of aging-specific biomarkers
- The relationship between aging and COVID-19
- Molecular mechanisms of osteosarcopenia and its systemic effects

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: aging, molecular mechanisms, senescence, lipid signaling, stem cell function

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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