Mitochondrial Dynamics and Endothelial Dysfunction: Implications for Metabolic Disorders

Mitochondria, once primarily recognized for their role in energy production, have emerged as crucial components in a wide array of cellular functions, particularly within the realm of endothelial cells. These organelles are integral to processes such as oxidative phosphorylation, reactive oxygen species generation, and calcium buffering, all of which contribute to cellular metabolic balance. The dynamic nature of mitochondria, characterized by their fission and fusion processes, is essential for maintaining their functionality and meeting cellular energy demands. However, disturbances in mitochondrial function can lead to endothelial dysfunction, a precursor to vascular diseases. Recent studies have highlighted mitochondrial biogenesis as a protective mechanism against metabolic stress, while increased oxidative stress and mitochondrial DNA translocation are linked to mitochondrial dysregulation and mitophagy. Despite these advances, the detailed mechanisms of mitochondrial interactions and their role in endothelial cell stress responses remain underexplored, particularly in the context of their communication with other organelles and their function as signal transmission hubs.

This Research Topic aims to explore the multifaceted role of mitochondria in endothelial dysfunction and its implications for metabolic disorders. By focusing on the interplay between mitochondrial dynamics, bioenergetics, and signaling pathways, the research seeks to uncover the contributions of mitochondria to endothelial dysfunction, a key feature of metabolic disorders such as diabetes, obesity, and cancer. The goal is to provide novel insights into the potential of targeting endothelial mitochondria as a therapeutic strategy to mitigate cardiovascular diseases, which are a leading cause of mortality and disability worldwide.

To gather further insights into the complex role of mitochondria in endothelial cells, we welcome articles addressing, but not limited to, the following themes:
- Mitochondrial dynamics and their impact on endothelial cell function;
- The role of mitochondrial biogenesis in endothelial stress responses;
- Mechanisms of mitochondrial communication with other organelles;
- Mitochondrial contributions to metabolic disorders and vascular diseases;
- Therapeutic potential of targeting mitochondrial pathways in endothelial dysfunction;
- Novel insights into extracellular mitochondria and cell-to-cell communication mechanisms.

Keywords: energy metabolism in endothelium, reactive oxygen species, endothelial dysfunction, functioning of mitochondria in metabolic disorders, endothelial mitochondria;, metabolic disorders

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.