Unraveling the Complexities of Premature Aging: Mechanisms and Interventions

Premature aging is a complex biological process that manifests clinically before the age of 35 and is considered atypical for the chronological age. Influenced by an array of factors including genetics, lifestyle, and environmental conditions, premature aging can lead to severe age-related phenotypes early in life. Certain genetic conditions, such as Hutchinson-Gilford syndrome and Werner syndrome, epitomize premature aging through specific mutations, exemplified by the LMNA gene mutation in progeria, which disrupts nuclear stability and accelerates cellular aging. This genetic component, combined with external factors like chronic stress and malnutrition, underlines the multifaceted nature of premature aging, emphasizing the need for a comprehensive understanding of its causes and effects.

This Research Topic aims to deepen the understanding of the mechanisms underpinning premature aging, explore preventive strategies, and develop potential therapeutic interventions. By examining the intricate interplay between genetic predispositions and environmental exposures, the research collected here seeks to illuminate the pathophysiological processes that drive premature aging, thereby identifying novel targets for intervention.

To gather further insights into premature aging, we welcome articles addressing, but not limited to, the following themes:

- Genetic and molecular bases of premature aging syndromes
- Impact of lifestyle and environmental factors on accelerating aging
- Advances in therapeutic strategies and preventive measures for premature aging
- Role of the immune system and chronic diseases in early onset aging
- Exploration of the gut microbiome’s influence on aging processes

We invite submissions in the form of original research, reviews, or case studies that provide valuable insights into premature aging. Contributions that elaborate on the progression, prognosis, and prevention of age-related diseases are particularly encouraged.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Premature aging, Mechanisms, Pathophysiology, Prevention, and Therapies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.