Tissue injury is one of the most common consequences of traumas, infections, or organ transplantations, contributing to an increase in mortality and the socioeconomic burden of patients. The mechanisms involved include the release of oxidants or pro-inflammatory cytokines. Numerous observations also support the inference that innate or adaptive immunity is notable in the pathogenetic tissue injury sequence. Understanding these mechanisms provide information to develop better risk prediction models, therapeutic interventions, and early biomarkers to monitor tissue damage. So far, biomarkers, including microRNAs and bioactive enzymes, have been proven promising candidates for therapeutic targets of specific tissue injuries in various clinical conditions.
Recent evidence suggests that endogenous mediators of inflammation play essential roles in tissue injury. However, the early molecular events and innate immune signaling networks that initiate tissue injury are still poorly defined. This Research Topic aims to provide a forum for fresh, rigorous, and promising research on the pathogenesis and development of tissue injury, addressing the dynamic molecular process of tissue injury underlying organ transplantation. In addition, we intend to gather pre-clinical and clinical data to provide a joint commentary on prediction molecules to guide perioperative management and enhance organ protection in transplant recipients.
We invite investigators to submit original research or review articles to document new data, review state-of-the-art techniques, or formulate new ideas to promote these advancements. We are interested in articles describing basic, pre-clinical, and clinical research in vivo and in vitro models. Potential topics include, but are not limited to:
• Recent advances in regulating innate and adaptive immunity in tissue injury after organ transplantation
• Modes of pathogen recognition and inflammatory signaling in organ ischemia/reperfusion injury (IRI) and organ transplantation.
• Roles of endogenous molecules in the pathogenesis of organ IRI-transplant inflammatory injury.
• New insights into the molecular mechanism of immune regulation in tissue injury and repair.
• Identification of new biomarkers in transplant-induced inflammatory responses.
• Pre-clinical and clinical application of specific biomarkers in solid organ transplantations.
Keywords:
Tissue injury, Biomarkers, Molecular signaling, Repair, Inflammation, Innate immunity, Islet Transplantation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Tissue injury is one of the most common consequences of traumas, infections, or organ transplantations, contributing to an increase in mortality and the socioeconomic burden of patients. The mechanisms involved include the release of oxidants or pro-inflammatory cytokines. Numerous observations also support the inference that innate or adaptive immunity is notable in the pathogenetic tissue injury sequence. Understanding these mechanisms provide information to develop better risk prediction models, therapeutic interventions, and early biomarkers to monitor tissue damage. So far, biomarkers, including microRNAs and bioactive enzymes, have been proven promising candidates for therapeutic targets of specific tissue injuries in various clinical conditions.
Recent evidence suggests that endogenous mediators of inflammation play essential roles in tissue injury. However, the early molecular events and innate immune signaling networks that initiate tissue injury are still poorly defined. This Research Topic aims to provide a forum for fresh, rigorous, and promising research on the pathogenesis and development of tissue injury, addressing the dynamic molecular process of tissue injury underlying organ transplantation. In addition, we intend to gather pre-clinical and clinical data to provide a joint commentary on prediction molecules to guide perioperative management and enhance organ protection in transplant recipients.
We invite investigators to submit original research or review articles to document new data, review state-of-the-art techniques, or formulate new ideas to promote these advancements. We are interested in articles describing basic, pre-clinical, and clinical research in vivo and in vitro models. Potential topics include, but are not limited to:
• Recent advances in regulating innate and adaptive immunity in tissue injury after organ transplantation
• Modes of pathogen recognition and inflammatory signaling in organ ischemia/reperfusion injury (IRI) and organ transplantation.
• Roles of endogenous molecules in the pathogenesis of organ IRI-transplant inflammatory injury.
• New insights into the molecular mechanism of immune regulation in tissue injury and repair.
• Identification of new biomarkers in transplant-induced inflammatory responses.
• Pre-clinical and clinical application of specific biomarkers in solid organ transplantations.
Keywords:
Tissue injury, Biomarkers, Molecular signaling, Repair, Inflammation, Innate immunity, Islet Transplantation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.