Mitochondrial research has significantly transcended its initial focus on oxidative phosphorylation and ATP production, unveiling diverse roles such as oxidative stress management, immune regulation, signal transduction, and cellular fate determination. These revelations have established mitochondrial dysfunction as a contributing factor to a wide array of diseases impacting virtually all physiological systems in humans. Noteworthy recent findings have demonstrated how mitochondrial DNA released from damaged mitochondria can initiate low-grade inflammation in various diseases, including cancer and aging, by stimulating innate immune responses. This intersection of metabolism, mitochondrial function, and immune system engagement is pivotal, suggesting a crucial area of study for improving healthcare outcomes.
This Research Topic aims to define and elucidate the intricate mechanisms that underlie mitochondrial dysfunction and its correlation with metabolic disorders and immune activation within disease contexts. The goal is to deepen the understanding of the fundamental genes and processes that govern mitochondrial interactions with metabolic and immune systems, shedding light on new methods to enhance mitochondrial health and, by extension, metabolic and immune system balance.
In pursuit of a comprehensive exploration of mitochondrial involvement in disease mechanisms, this Research Topic encourages submissions that are oriented within these defined parameters. We invite contributors to focus on a range of pertinent themes including, but not limited to:
• Key genes and mechanisms inducing mitochondrial dysfunction in diseases.
• Linkages between mitochondrial dysfunction, metabolic disorders, and immune activation.
Impact of mitochondrial dysfunction on cell injury and fate decisions.
• Strategies for mitigating mitochondrial dysfunction and preventing related metabolic and immune disruption.
• Potential therapeutic targets to restore mitochondrial function and reduce disease impact.
We welcome the submission of original research articles, timely reviews or mini reviews, rapid communications, and expert perspectives. It is important to note that pure bioinformatic analyses without experimental validation do not fall within the scope of this Research Topic.
Keywords: Multi-omics studying
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
