Gene Editing in Immune Cell Therapy

Gene editing, particularly with the CRISPR-Cas9 system, has become a cornerstone in the evolution of immune cell therapies, offering a means to enhance T cell specificity, counteract the immunosuppressive tumor microenvironment, and improve treatment safety and efficacy. By engineering T cells to recognize tumor-associated antigens more accurately and overcome intrinsic limitations, gene editing paves the way for personalized treatments that could be more effective against cancer. Despite the promise, challenges such as off-target effects, manufacturing scalability, and regulatory compliance must be addressed to realize the full therapeutic potential of this technology.

Recent advances have introduced more precise editing tools, successful clinical applications of CAR-T therapies, and innovative manufacturing processes, all of which are pushing the field towards safer and more effective personalized treatments. As the development of gene editing in immune cell therapy has recently seen a surge in interest, it is crucial to summarize the existing challenges and reveal the current research progress in this dynamic field.

The aim of the current Research Topic is to cover promising, recent, and novel research trends in the Gene editing in immune cell therapy. Areas to be covered in this Research Topic may include, but are not limited to:

· Precision Gene Editing Techniques
· Enhancing T Cell Therapies
· Overcoming Tumor Heterogeneity
· Tumor Microenvironment Modulation
· Immune Cell Persistence and Memory
· Combination Therapies

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Systematic Review

Keywords: Gene editing, immune cell therapy, CRISPR-Cas9, T cell engineering, cancer treatment

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.