A focus on the past, present and future of lens research

The field of lens research holds an invaluable place within both scientific inquiry and medical application, serving as a model for understanding development, cellular ageing, and as an avenue for exploring corrective strategies. The importance of lens research is underscored by the prevalence of lens-related conditions such as cataracts and presbyopia. Cataracts alone lead to tens of millions of cases worldwide requiring surgery, the most frequently performed surgical procedure globally. Yet, complications from wound-healing responses substantially impact visual outcomes, emphasising the urgent need for further research in both healthy lens biology and pathological conditions. Such endeavours could significantly enhance patient management and thereby improve societal wellbeing.

This Research Topic strives to reflect on foundational discoveries that have shaped current lens research while simultaneously exploring future horizons in technologies and therapeutic approaches. We aim to gather a collection of works that highlight the contributions of key researchers and reveal how these breakthroughs have established ongoing research trajectories. Capturing the current state of knowledge, the collection will emphasise significant advances, introduce emerging technologies, and propose future strategies to bolster lens research, ultimately benefiting patients and society alike.

To expand on these goals, submissions across the broad spectrum of lens research are encouraged. While perspectives and reviews are particularly sought after, articles showcasing remarkable advancements or innovative technologies contributing to the field are also welcome. The collective aim is to weave together the rich tapestry of past and present insights, creating a foundation upon which future research can build.

To gather further insights into the expansive realm of lens research, we invite articles covering, but not limited to, the following topics:

- Lens development
- Lens anatomy and ultrastructure
- Lens biomechanics
- Optical properties of the lens
- Channels, barriers, and fluid circulation in the lens
- Proteomics
- Genomics
- Growth factors and signalling pathways
- Presbyopia
- Cataract formation
- Redox biology in the lens
- Lens regeneration, stem cells, and organoids
- Cataract surgery
- Intraocular lenses
- Posterior capsule opacification
- Health economics and social impact of lens disorders

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Lens, Cataract, Posterior Capsule Opacification, Transparency, Development, Proteomics, Channels, Genomics, Aging, Presbyopia, Accommodation, Cataract Surgery, Differentiation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.