Unraveling Hematopoietic Stem Cell Aging: Pathways and Therapeutic Potential

Hematopoietic stem cells (HSCs) are essential for the continuous production of blood cells throughout an individual's life. These cells reside primarily in the bone marrow and are responsible for maintaining blood homeostasis by differentiating into various blood lineages. As individuals age, HSCs undergo significant functional changes, leading to reduced regenerative capacity and altered differentiation potential. This can result in a higher incidence of blood-related disorders such as anemia, myelodysplastic syndromes, and leukemia. Understanding the underlying mechanisms of HSC aging is crucial, as these insights could lead to novel interventions that promote healthy aging and combat age-associated hematological diseases.

This Research Topic aims to elucidate the mechanisms through which aging affects HSC function and contributes to dysfunction. By exploring the molecular, cellular, and systemic changes that occur with age, we seek to advance knowledge on preventing and treating age-related hematopoietic disorders.

We welcome submissions that cover the following topics.

Characterize Age-Related Changes:
1. Explore how aging affects HSC self-renewal, differentiation, and function.
2. Examine changes in the HSC microenvironment and niche interactions.

Molecular Mechanisms:
1. Investigate genetic and epigenetic alterations in aging HSCs.
2. Study the impact of senescence and metabolic changes on HSC aging.

Health Implications:
1. Analyze links between HSC aging and increased vulnerability to hematological disorders.
2. Assess the connection between HSC aging and overall immune system decline.

Innovative Therapies:
1. Develop strategies to rejuvenate aged HSCs using pharmacological or genetic approaches.
2. Explore stem cell transplantation and gene editing as potential interventions.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Aging, Hematopoiesis, Cellular Senescence, Regenerative Capacity, Bone Marrow Niche

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.