Chronicles of Aging: Uncovering Its Role in Reproductive Health

Reproductive aging in both males and females is characterized by a decline in reproductive capacity due to numerous physiological changes. In women, particularly those above 35, there is a notable decrease in ovarian function leading to reduced fertility and increased risk of pregnancy complications. This decline is associated with factors like follicle depletion, diminished oocyte quality, and hormonal imbalances. Contributing elements include oxidative stress, mitochondrial anomalies, telomere erosion, meiotic errors, and genetic modifications, each influencing the overall health of the reproductive system. The effects of external factors such as inflammation and lifestyle habits like smoking further exacerbate these changes.

This Research Topic aims to comprehensively explore the intricacies of aging in the reproductive systems of male and female bodies, particularly focusing on the correlations between advanced reproductive age and pregnancy outcomes. Key objectives include identifying biological markers predicting successful pregnancy, and examining the influences of mitochondrial dysfunction, reactive oxygen species, and placental aging. Furthermore, this Research Topic seeks to evaluate how genetic changes and inflammatory responses impact reproductive health and the potential interventions to mitigate these effects.

To gather further insights into the boundaries of hormonal, cellular, and genetic factors in reproductive aging, we welcome articles addressing, but not limited to, the following themes:

1. Biological pathways associated with reproductive aging.
2. The critical role of oxidative stress, particularly in complex pregnancies.
3. Investigating telomerase activity in infertility and reproduction.
4. The influence of Sirtuins on embryo development and gamete quality.
5. Effects of parental age on fetal development and pregnancy outcomes.

This comprehensive examination aims to bridge gaps in understanding the biological, physiological, and environmental interactions that occur in reproductive aging, offering a clearer path to mitigating the risks associated with late pregnancies.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Reproduction, oxidative stress, reproductive aging, telomerase activity, hormonal disbalance

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.