Global Perspectives on Genetic Diagnosis and Treatments for Inherited Retinal Diseases

In the field of ophthalmology, Inherited Retinal Diseases (IRDs) represent a challenging frontier due to their progressive and degenerative nature. Historically, effective treatments have been elusive, but recent breakthroughs in genetic screening and engineering are heralding a new era of possibilities. However, most of these advancements have been concentrated in Western countries, creating a geographical imbalance in our understanding and treatment approaches. Given the genetic diversity of IRDs across different populations, it is vital to broaden research efforts globally to tailor interventions more effectively and enhance outcomes for diverse populations.

This Research Topic aims to address the genetic diversity of IRDs across the globe and to catalyze the advancement of treatments worldwide. Recognizing the disparities in research and development, we are keen to include insights from regions with nascent genetic diagnosis capabilities, alongside contributions from well-established research ecosystems. We encourage submissions spanning basic research to clinical trials, all geared towards refining our understanding and enhancing treatment protocols for better patient outcomes universally.

To achieve comprehensive advancements in the field, we invite manuscripts that explore a variety of aspects pertaining to IRDs:

· Genetic screening techniques specific to IRDs
· Studies correlating genotypes with phenotypes
· Detailed case reports
· Applications of next-generation sequencing
· Use of both viral and non-viral vectors in treatment
· Gene editing innovations
· Animal model studies
· iPSC-based approaches for disease modeling
· New study protocols
· Advances in gene and cell therapy
· Neuroprotective strategies in treatment
· Approaches to improving low-vision care

By casting a wide net over these topics, we aim to accumulate a breadth of knowledge that will inform and enhance global treatment strategies for IRD patients.

Keywords: Inherited retinal diseases, Basic, clinical, and translational studies, Genotype and phenotype Gene engineering and gene therapy, Low-vision care, Global diversity, inclusion

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.