The Impact of Biological Sex on Transplantation: From Bench to Bedside

To date, both basic and clinical research have predominantly focused on male patients, animals, and cells, often overlooking the critical role of biological sex in physiological and pathological processes, including transplantation. In recent years, however, there has been growing recognition of the undeniable significance of biological sex in both research and clinical practice.

With this Research Topic, our aim is to consolidate and advance understanding of how biological sex shapes transplant outcomes, immune responses, and therapeutic strategies. By fostering greater awareness among researchers and clinicians, we hope to contribute to improving outcomes and care for transplant patients.

This Research Topic is looking for high-quality research concerning; Basis of sex differences in transplantation (e.g., immunological, donor-recipient sex mismatches, IRI); Clinical implications (e.g. immunosuppression, outcomes, pregnancy relevance); Sex differences in biomarkers and diagnostics; Methods and challenges in studying sex differences in transplantation. This Research Topic accepts multiple article types including Reviews, meta-analyses, original research, opinions, case reports, and methods articles.