Reactive Oxygen Species: Architects of Aging and Cellular Senescence

Reactive Oxygen Species (ROS) are pivotal in the aging process, influencing cellular functions and longevity. The production and accumulation of ROS within cells are thought to be one of the fundamental molecular mechanisms driving the aging process. Recent research links excessive ROS levels to cellular damage and senescence, contributing to the phenotypes associated with aging and the pathogenesis of age-related diseases. This has ushered in debates about the potential benefits of modulating ROS levels and the paradoxical roles ROS play in cellular signaling and homeostasis. Despite intensive study, significant gaps remain in understanding the nuanced roles of ROS in aging, necessitating continued investigation into their sources, targets, and mechanisms of action.

This Research Topic aims to probe deeper into the dual roles of ROS as both damaging agents and signaling molecules in the aging process. Studies might explore the precise molecular pathways through which ROS influence aging and longevity, the development of innovative strategies to manipulate ROS levels in various tissues, and how ROS modulation impacts age-related diseases.

To gather further insights into the complex relationship between ROS and aging processes, we welcome articles addressing, but not limited to, the following themes:

1. Sources and types of ROS involved in aging
2. Mechanisms by which ROS promote cellular aging
3. The role of antioxidant systems in age-related ROS management
4. The impact of lifestyle, diet, and environmental factors on ROS levels in aging
5. Prospective therapeutic approaches to mitigate ROS-induced aging effects

A comprehensive exploration of these areas will be pivotal in understanding how ROS contributes to the aging process and how its modulation can extend health span and improve quality of life in older populations.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Reactive Oxygen Species Cellular Senescence Antioxidant Defense Aging Biomarkers Therapeutic Modulation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.