Advances in Omic technologies are revolutionizing our understanding of transplantation and transfusion medicine, providing new perspectives on genetic, proteomic, metabolomic, and transcriptomic landscapes. These innovations enable deeper insights into the complex interactions underlying donor-recipient compatibility, immune responses, and clinical outcomes. Beyond genomics, the integration of multi-omics approaches offers unprecedented opportunities to dissect the molecular mechanisms driving acute and chronic complications, improve precision matching, and uncover novel biomarkers for diagnosis and prognosis. The study of population- and ethnicity-specific variations, particularly in HLA, KIR, blood group, and related genes, remains critical to achieving equity in transfusion and transplantation medicine. Multi-omics studies provide a unique opportunity to bridge these gaps, enabling more comprehensive profiling of immune, inflammatory, and metabolic pathways to inform personalized and equitable healthcare strategies.
This Research Topic invites contributions that explore the latest advancements in genomics and other omics technologies, aiming to enhance our understanding of the molecular underpinnings of transplantation and transfusion biology. We welcome original research, reviews, short communications, and case studies that focus on—but are not limited to—the following themes:
- Genetic Epidemiology and Beyond: Studies of HLA, KIR, HNA, RBC alleles, and other molecular markers using genomic, proteomic, or transcriptomic approaches in diverse populations.
- Multi-Omics Integration: Research leveraging combinations of genomics, transcriptomics, proteomics, and metabolomics to understand donor-recipient compatibility, immune modulation, and clinical outcomes.
- Innovative Methodologies: Development and application of advanced Omic technologies, bioinformatics tools, and systems biology approaches in transfusion and transplantation medicine.
- Population-Specific Studies: Exploration of underrepresented populations to illuminate genetic and molecular diversity and its implications for equitable healthcare practices.
- Disease Associations and Biomarkers: Discovery of novel molecular signatures associated with transplant rejection, transfusion complications, and related conditions.
By expanding the scope to include multiple omics, this Research Topic aims to foster interdisciplinary collaboration and inspire innovative solutions for challenges in transfusion and transplantation medicine. Join us in advancing this vital field by contributing your insights and discoveries.
Keywords: Genomics, Transfusion, Multi-Omics Integration, HLA, KIR, RBC, Biomarkers, Donor-Recipient Compatibility, Immune Modulation, Precision Medicine
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
