The restoration of glycemic control through islet transplantation currently remains as one of the only approaches to achieve insulin independence for type-I diabetics. However, achieving long-term success requires overcoming significant obstacles, including immune rejection, islet survival, and functional longevity. Innovations in immunomodulation strategies, biomaterials for islet encapsulation, and novel transplantation approaches are paving the way for enhanced outcomes. Furthermore, emerging technologies such as engineered islets, stem cell-derived islets, and alternative transplant sites present exciting opportunities to expand the potential of this therapy.
This article collection aims to explore novel approaches for advancing pancreatic islet transplantation. By focusing on immune modulation, biomaterial engineering, and cellular engineering, this collection seeks to highlight innovative solutions to current challenges. The goal is to foster interdisciplinary collaboration and disseminate new insights that will pave the way for improved clinical outcomes and enhanced islet survival for the treatment of Type-I Diabetes.
We invite researchers, clinicians, and engineers to contribute original research articles, reviews, perspectives, and case studies that explore the latest developments in islet transplantation and related technologies. Topics of interest include, but are not limited to:
• Advances in immune modulation techniques to prevent islet rejection.
• Biomaterials for islet encapsulation and their role in immune protection and vascular integration.
• Stem cell-derived or engineered islets for transplantation.
• Alternative transplantation sites and methods for enhancing islet engraftment and function.
• Novel approaches to improving islet viability, survival, and scalability for clinical applications.
• Preclinical and clinical studies on islet transplantation outcomes.
• The integration of emerging technologies, such as bio-fabrication, 3D bioprinting, and organ-on-chip models, into islet transplantation research.
Authors are encouraged to submit manuscripts that provide novel insights, address current barriers, or explore interdisciplinary approaches to enhance the efficacy and accessibility of islet transplantation as a therapeutic modality for diabetes.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
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Case Report
Classification
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FAIR² Data
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
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