Insights in Vascular Physiology: 2025

This Research Topic is part of the Insights in Vascular Physiology series:
Insights in Vascular Physiology: 2024

We are now in the third decade of the 21st Century, and especially in recent years, scientists have made exceptional achievements, leading to major advancements in the fast-growing field of Vascular Physiology. This Frontiers Research Topic aims to highlight the latest advancements in vascular physiology and pathophysiology, including novel developments, current challenges, latest discoveries, recent advances, and future perspectives. It is edited by Topic Editors Prof. Christopher Garland (University of Oxford, UK), Prof. Luis A. Martinez-Lemus (University of Missouri, USA), Prof. Francesco Moccia (University of Molise, Italy), and Prof. Andrew Braun (University of Calgary, Canada).

We welcome submissions related to, but not limited to, the following topics:

• Mechanisms of Abdominal Aortic Aneurysm (AAA) progression to rupture to identify targets for its therapeutic amelioration;
• Integration of shear stress mechanotransduction in endothelial cells;
• Mechanisms of endothelial to smooth muscle cell communication across vascular beds;
• Mechanisms of cerebral capillary perfusion in health and disease;
• Endothelial contributions to metabolic dysfunction;
• Vascular effects of obesity and how this may be mitigated by new anti-obesity drugs;
• Lipid-proteins interactions and lipidomics in vascular dysfunction;
• Impact of microbiome on vascular physiology and health and disease;
• Vascular aging;
• Regulation of the cerebral microcirculation;
• Regulation of the coronary microcirculation - with special interest in dysfunction particularly in angina or ischemia with no obstructive coronary disease (ANOCA/INOCA);
• Ion channels in vascular and endothelial function;.
• Mechanisms of neurovascular coupling in health and diseases;
• Role of endothelial progenitor cells in vascular repair and regeneration;
• The potential physiological or pathophysiology effects of endothelium-derived extracellular vesicles;
• The endothelium as potential regulator of neurodegenerative disease by controlling blood-brain barrier permeability.

Topic Editor Prof. Luis A. Martinez-Lemus holds a patent entitled "Neuraminidase inhibition to improve glycocalyx volume and function to ameliorate cardiovascular diseases in pathologies associated with glycocalyx damage". Topic Editor Prof. Andrew P. Braun holds a patent entitled "Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase" (U.S. patent # 6,518,245), which is not directly related to the current Research Topic. Topic Editors Prof. Francesco Moccia and Prof. Christopher Garland declare no conflicts of interest.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: vascular physiology, vascular mechanotransduction, acute and chronic control of vascular diameter, microcirculation, ion channels, vascular aging

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.