Cell Death Pathways in Bronchopulmonary Dysplasia: Mechanisms and Therapeutic Targets

Bronchopulmonary dysplasia (BPD) is a severe chronic lung disease primarily affecting preterm infants, posing persistent challenges in neonatal intensive care. Despite improvements in treatment, BPD continues to cause significant long-term respiratory problems. Recent studies have revealed a complex involvement of various cell death pathways—including apoptosis, necrosis, necroptosis, ferroptosis, and others—in the development of BPD. Understanding these pathways is crucial for devising new treatments aimed at reducing lung damage in these vulnerable infants.
This Research Topic aims to delve deeply into the molecular mechanisms of cell death in BPD, emphasizing the roles of different cell death modes and their interactions with inflammatory responses and oxidative stress. The goal is to identify new therapeutic targets by understanding these intricate interactions and to stimulate advanced research that could lead to innovative treatments.
To provide comprehensive insights, the Research Topic will cover:
o The spectrum of programmed and non-programed cell death processes (such as apoptosis, necrosis, ferroptosis, pyroptosis, etc.) and their contributions to BPD pathophysiology.
o The interplay between cell death mechanisms and other cellular processes like inflammation, mitochondrial dysfunction, and angiogenesis.
o The use of animal models and in vitro systems to investigate cell death in the context of BPD.
o The development and implications of emerging biomarkers for diagnosing, prognosticating, and monitoring treatments related to BPD.
o Innovative therapeutic strategies that target specific cell death pathways in the treatment of BPD.
Contributions to this Research Topic can include:
o Original research articles that unveil new data on the mechanisms of cell death in BPD.
o Comprehensive reviews that synthesize existing knowledge on cell death pathways and their impacts on BPD.
o Mini-reviews or opinion pieces that present fresh perspectives on less explored aspects of cell death in neonatal lung diseases.
o Methodological papers describing new approaches for investigating cell death in BPD models.
o Clinical studies that assess biomarkers or therapeutic interventions aiming at cell death pathways in the management of BPD.

Keywords: cell death, apoptosis, Bronchopulmonary dysplasia (BPD), Inflammatory responses, Oxidative stress, Therapeutic targets, Molecular mechanisms

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.