Aging brain: brain health and neuroprotective strategies

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As global life expectancy continues to rise, understanding the complexities of the aging brain has become increasingly critical. Aging, while a natural process, brings about structural and functional changes in the brain that can affect cognitive health and overall neurological function. These changes can lead to age-related cognitive decline and an increased risk of neurodegenerative diseases such as Alzheimer's and Parkinson's. Research in this area is crucial to unraveling the mechanisms that drive these changes and identifying the factors that can help maintain brain health and functionality throughout aging.

The primary goal of this Research Topic is to explore comprehensive strategies for preserving brain health and developing neuroprotective interventions for the aging population. We aim to address the pressing problem of age-related cognitive decline by encouraging research that elucidates the biological, environmental, and lifestyle factors impacting brain aging. This includes identifying potential biomarkers for early detection, investigating the roles of genetics and epigenetics, and developing novel therapeutic approaches. By bringing together diverse research perspectives, we aspire to enhance our ability to prevent or mitigate the impact of neurodegenerative conditions, ultimately improving quality of life for older adults.

This Research Topic invites contributions that expand our understanding of the aging brain and strategies for maintaining cognitive health. We welcome original research articles, reviews, and case studies covering, but not limited to, the following themes:

• Cellular and molecular mechanisms underlying brain aging and neurodegeneration

• Identification and validation of biomarkers for early detection of cognitive decline

• Role of genetics and epigenetics in brain aging

• Impact of lifestyle factors (e.g., diet, exercise, cognitive training) on brain health

• Development and efficacy of pharmacological and non-pharmacological interventions

• Neuroprotective strategies and their implementation in clinical settings

• Aging-related changes in brain connectivity and functional networks

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Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Brain health, ageing brain, ageing neuroscience

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.