Reviews In: Molecular mechanisms of chronic pain and neuropathic pain pathways

Pain, especially chronic and neuropathic pain, represents a complex physiological and neurological challenge affecting millions worldwide. Recent scientific endeavours have begun to unravel the intricate molecular and cellular processes that underlie the transition from acute to chronic pain states. This involves a dense interaction between neurotransmitters, receptors, and various ion channels, along with a deeper understanding of neuropathic pathways through mechanisms like peripheral and central sensitization and nerve injuries. However, despite these advances, significant gaps remain in fully elucidating the pathways and effectively treating these pain conditions.



This Research Topic aims to compile a comprehensive analysis of the latest research and emerging trends in the molecular mechanisms underlying chronic and neuropathic pain. By focusing on diverse aspects such as inflammatory mediators, genetic and epigenetic influences, and the modulation of pain at both central and peripheral levels, this collection strives to provide a holistic view of the current landscape and foster discussions that could lead to novel therapeutic strategies.



To gather further insights into this multi-faceted topic, we welcome articles addressing, but not limited to, the following themes:



Detailed molecular dynamics in the transition from acute to chronic pain

Mechanistic insights into neuropathic pain pathways

Inflammatory processes and their molecular underpinnings in pain contexts

The role of genetics and epigenetics in pain perception and chronic pain development

Modulatory roles of central and peripheral systems in pain management

The impact of psychosocial and environmental factors on pain perception

Contributions of neuroplasticity and memory processes in chronic pain

Emerging biomarkers for pain assessment

Technological advancements in pain research methodologies

Clinical and translational research efforts bridging molecular insights to pain management practices

Drug discovery and development for neuropathic pain

Submissions of original research, reviews, and method papers in these areas are encouraged to enrich our understanding and intervention strategies for chronic pain.