Infection-Mediated Inflammation that Promotes Cancer Initiation and/or Progression - Volume II

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About this Research Topic

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Background

Building on the success of "Infection-Mediated Inflammation that Promotes Cancer Initiation and/or Progression", we are pleased to announce the launch of Volume II.

Microorganisms have been shown to significantly impact cancer development, often by mediating inflammation and DNA damage. Viruses like the Hepatitis B virus, Hepatitis C virus, Epstein-Barr virus, and Human papillomavirus have been correlated with cancers, including liver cancer, Burkitt's lymphoma, and cervical cancer. Similarly, bacteria such as Helicobacter pylori are linked to gastric and colorectal cancers. In contrast, others like Chlamydia Trachomatis, Streptococcus Bovis, and Clostridium Species are associated with ovarian, colorectal, and prostate cancers, respectively. Aside from these known associations, microbial dysbiosis poses a further risk factor for cancer onset, with parasites like Fusobacterium nucleatum, Bacteroides fragilis, and E. coli playing notable roles.

The connection between microbes and cancer is not yet completely understood, involving a complex interplay of genetic, epigenetic, microbial, and environmental factors which collectively influence cancer initiation and progression. Despite known pathways involving inflammation, DNA mutations, and intestinal permeability, numerous mechanisms remain undiscovered. Particularly, the effects of co-infections and the conjunction between environmental toxicants, such as smoking, and microbial influence on cancer development, need further exploration. This understanding could lead to novel preventive strategies, where targeting microbial pathogenic pathways might reveal potential anticancer activities from antibiotics, antivirals, dietary metabolites, probiotics, prebiotics, oncolytic agents, and vaccines.

This Research Topic aims to advance the understanding of microbial pathways involved in cancer through original research and review articles that elucidate the roles and interactions of microbes in cancer pathogenesis, delve into the effects of co-infections, and investigate the intersection of microbes with genetic and environmental factors in cancer development. Furthermore, it seeks contributions on antimicrobial agents and dietary interventions that could mitigate the risk of cancer.

To gather further insights into this compounded landscape, we welcome articles addressing, but not limited to, the following themes:

o The role of microorganisms in cancer development
o Microbial pathways and pathogenesis in cancer
o Effects of co-infections in cancer progression
o Interactions between microbes and environmental toxicants in cancer
o Antimicrobial strategies and dietary interventions to reduce cancer risk

We invite the submission of original research articles and review articles that focus on these intricate connections and therapeutic potential in the fields of pathology, microbiology, and oncology.

Keywords: Microbe, Infection, Inflammatory Response, Pathogenesis, Cancer, Therapy, Caner Progression, Microbial Pathway

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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