Network neuroscience in neuropsychiatric disorders

Neuropsychiatric disorders, such as Alzheimer's disease, Huntington's disease, Parkinson’s disease, Major Depressive Disorder, Schizophrenia, Bipolar Disorder, and Autism Spectrum Disorder, are characterized by complex alterations in brain structure and function. These disorders often involve disruptions in the connectivity and communication between brain regions/networks, leading to cognitive, emotional, and behavioral impairments. Over the past two decades, advances in neuroimaging and network neuroscience have provided new tools to map, analyze, and model the brain as a complex network, offering insights into the neural mechanisms underlying these disorders.

Network neuroscience leverages the principles of graph theory and network science to study the brain as a multiscale, interconnected system. By modeling the brain as a network of nodes (e.g., brain regions) and edges (e.g., structural or functional connections), researchers can investigate how disruptions in network topology and dynamics contribute to the pathophysiology of neuropsychiatric disorders. This approach has led to the identification of key network properties, such as small-world architecture, modularity, and hub connectivity, which are often altered in these conditions.

Despite significant progress, our understanding of how network disruptions contribute to neuropsychiatric disorders remains incomplete. This Research Topic aims to address this gap by focusing on the development, validation, and application of novel network modeling methods to study neuropsychiatric disorders. We welcome contributions that explore, but are not limited to, the following areas:

a) Development of Novel Network Modeling Methods

b) Validation of Network Models

c) Applications of Network Models in Neuropsychiatric Disorders

d) Cross-Disorder Comparisons

e) Multiscale Network Modeling

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Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Brain connectivity, Brain network modeling, Static brain networks, Dynamic brain networks, Neuropsychiatric disorders

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.