Exploring Aging Biology in Skin: From Mechanisms and Assessments to Innovative Anti-Aging Strategies

The field of aging research is gaining unprecedented attention as the global population continues to grow older. Central to this research is an exploration of the biological mechanisms of aging which led to the identification of new research avenues. Recent advances have highlighted areas such as "inflammaging," which highlights the role of chronic low-grade inflammation in the aging process, with key cells and cytokines emerging as potential targets for therapy. Furthermore, the role of the microenvironment, crucial in maintaining tissue homeostasis and repair via stem cell activity and extracellular matrix (ECM) synthesis, is increasingly recognized. Additionally, accurate assessment of aging is equally important. Various scales and detection instruments have been developed to provide measurable biological aging metrics, which can help evaluate the efficacy of different anti-aging interventions, especially in regenerative medicine. However, despite progress, gaps persist in fully understanding these processes and effectively translating findings into targeted anti-aging interventions.

This Research Topic aims to provide an integrated understanding of aging by addressing fundamental mechanisms and exploring their potential therapeutic value, with a particular focus on the skin. The main objective is to investigate key areas such as stem cell function, the regulatory role of the micro-environment on cellular behavior, and the molecular underpinnings of inflammaging. Additionally, it seeks to identify emerging applications within regenerative medicine, novel materials, and other innovative technologies with a focus on bridging basic research and clinical practices. By fostering a comprehensive understanding of these aspects, this Research Topic endeavors to guide future research and promote advancements in anti-aging therapies, encouraging collaboration across scientific and clinical domains.

To gather further insights into the aging mechanisms and anti-aging, with a particular focus on the skin, we welcome articles addressing, but not limited to, the following themes:
o Immune cell response in skin aging
o Regulation and activity of stem cells in skin aging
o Impact of the microenvironment on skin aging
o Identification of novel therapeutic targets
o Methods for assessing biological aging and efficacy of interventions
o Applications of innovative technologies, devices, and materials (both biological and biotechnological) in anti-aging

We are interested in a variety of manuscript types, including original research articles, reviews, perspectives, and opinion pieces, that provide novel insights and advancements in the field of aging and anti-aging strategies.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review

Keywords: Skin Aging, mechanism, assessments, anti-aging treatments, Innovative Technologies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.