Diabetes mellitus is a systemic disease with profound and often underappreciated impacts on cardiac structure and function. In particular, the interplay between diabetes and cardiac electrophysiological pathologies—including arrhythmias, conduction defects, and myocardial electrical remodelling—presents unique diagnostic and therapeutic challenges.
Emerging evidence suggests that the roots of these disturbances can be traced to specific histopathological alterations in myocardial tissue, such as interstitial fibrosis, microvascular disease, cellular apoptosis, and changes in ion channel expression. However, comprehensive pathological characterisation integrating molecular, cellular, and tissue-level findings with evolving diagnostic modalities remains limited.
This Research Topic aims to bridge the gap between innovative diagnostic techniques and underlying pathological mechanisms in diabetic cardiac complications. We welcome studies that use advanced histopathological approaches—such as immunohistochemistry, electron microscopy, tissue-based omics, and molecular pathology—to dissect the structural and functional changes underlying electrophysiological abnormalities in diabetic hearts.
Submissions may also address correlations between pathological findings and novel diagnostic tools (e.g., tissue imaging, digital pathology, artificial intelligence-driven analysis), as well as clinical pathological studies investigating the translational relevance of tissue-based discoveries.
We encourage the submission of original research, reviews, case reports, and technical advances that address, but are not limited to, the following areas:
• Histopathological characterisation of cardiac tissue in diabetes complicated by electrophysiological disturbances. • Molecular and cellular markers linked to arrhythmogenic risk in diabetic heart pathology. • Advances in biopsy, imaging, and tissue analysis relevant to diagnosing diabetic cardiac complications. • Integrative studies connecting non-invasive electrophysiological diagnostics with post-mortem or biopsy-proven pathology. • Descriptions of experimental models mirroring the pathological features of diabetic cardiac tissue.
By focusing on pathology-driven insights, this Research Topic seeks to enhance our understanding of the mechanisms underlying cardiac electrophysiological disorders in diabetes, foster innovation in diagnosis, and ultimately pave the way for more targeted, tissue-informed therapeutic strategies.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Clinical Trial
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
