Complex Issues | List of Frontiers open access articles

Original Research

Published on 27 Feb 2026

Generation and preclinical characterization of a novel bispecific CD19-TCRgammadelta antibody for the treatment of B cell acute lymphoblastic leukemia

in Cancer Immunity and Immunotherapy

Joseph Kauer
Fabian Vogt
Sebastian Hörner
Valentin Schmidt
Carsten Müller-Tidow
Simon Raffel
Helmut R. Salih
Gundram Jung
Martin Pflügler

Frontiers in Immunology

doi 10.3389/fimmu.2026.1728424

179 views

Review

Published on 27 Feb 2026

Multimodal therapeutic efficacy assessment of vagus nerve stimulation in stroke: integrated application of imaging, electrophysiological, and behavioral indicators

in Neurorehabilitation

Tiancong Fu
Hui Zhang
Haoran Ma
Zhen Liu
Yujia Li
Tinghe Zhang
Ningcen Li
Jingyu Zhang
Xiyou Hu
Zelin Chen

Frontiers in Neurology

doi 10.3389/fneur.2026.1788506

118 views

Review

Published on 27 Feb 2026

Advances in the immunosuppression of porcine reproductive and respiratory syndrome virus

in Veterinary Infectious Diseases

Huawei Li
Chen Lv
Ruining Wang
Xuyong Zhao
Liangzong Huang
Mengmeng Zhao

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1775261

197 views

Original Research

Published on 27 Feb 2026

Dynamic TyG trajectories cumulative TyG burden are associated with in-hospital mortality in acute brain injury: a multicenter interpretable machine-learning analysis

in Nutrition, Psychology and Brain Health

Juan Wang
Zheng Peng
Man-Man Xu
Meng-Lian Duan
Chun-Hua Hang
Peng-Lai Zhao

Frontiers in Nutrition

doi 10.3389/fnut.2026.1761240

141 views

Review

Published on 27 Feb 2026

Dual PD-1 and CTLA-4 targeting in endometrial carcinoma: integrating efficacy, toxicity, and biomarkers into clinical practice

in Cancer Immunity and Immunotherapy

Lan Zhong
Liang Song

Frontiers in Immunology

doi 10.3389/fimmu.2026.1771548

Review

Published on 27 Feb 2026

Reflections on prevention and treatment of post-thyroidectomy hypoparathyroidism: current management approaches and future prospects

in Thyroid Endocrinology

Jia Li
Zilai Hu
Zhiyuan Ma
Guoli Feng
Lanhai Zhang
Suansuan Zhu
Jinyan Hu
Wei Han
Taolang Li

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1768391

Perspective

Published on 27 Feb 2026

Milena Auretta Rosso first female Italian neurosurgeon

in Healthcare Professions Education

Keyvan Mostofi
Gianluca Caragliano

Frontiers in Medicine

doi 10.3389/fmed.2026.1712773

105 views

Case Report

Published on 27 Feb 2026

Case Report: Morphologically striking eruptive xanthomas with lobulated papules: a sentinel sign of severe metabolic dysregulation

in Clinical Diabetes

Tiantian Lu
Fuyuan Zhuge
Wei Cai
Xiaofang Zhang
Dajun Lou
Dihua Huang

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1764866

Original Research

Published on 27 Feb 2026

GFTrans: an on-the-fly static analysis framework for code performance profiling

in Data Mining and Management

Jie Li
Yunbao Wen
Jingxin Liu
Biqing Zeng
Seyedali Mirjalili

Frontiers in Big Data

doi 10.3389/fdata.2026.1779935

114 views

Original Research

Published on 27 Feb 2026

Impact of biliary fungal contamination on outcomes after pancreaticoduodenectomy for pancreatic cancer

in Cancer Epidemiology and Prevention

Jeremy Chang
Sophia Xiao
Yutao Su
Scott K. Sherman
James R. Howe
James P. De Andrade
Hisakazu Hoshi
Carlos H. F. Chan

Frontiers in Oncology

doi 10.3389/fonc.2026.1776853

Original Research

Published on 27 Feb 2026

Moisture-driven shifts in the fermentation characteristics and microbial community of alfalfa silage treated with different additives

in Animal Nutrition and Metabolism

Run Gao
Bo Wu
Zhiqiang Sun
Zhu Yu
Chunlin Jia
Daniel Basigalup
Guoliang Wang

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1748640

Original Research

Published on 27 Feb 2026

Dysbiosis of intestinal microbiota in patients with neuromyelitis optica spectrum disorders

in Multiple Sclerosis and Neuroimmunology

Qin Du
Xiaofei Wang
Ziyan Shi
Hongxi Chen
Ying Zhang
Rui Wang
Zichao Mou
Lingyao Kong
Hongyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1747643

Original Research

Published on 27 Feb 2026

Combination of single-cell and bulk RNA-seq reveals changes in the immune landscape in osteomyelitis

in Inflammation

Zhenhua Zhu
Xiaopeng Jing
Jun Chen
Siteng Li
Jie Tan
Ji Zeng
Zheng Jin

Frontiers in Immunology

doi 10.3389/fimmu.2026.1746323

128 views

Original Research

Published on 27 Feb 2026

Prevalence and associated factors of diabetic kidney disease among rural patients with type 2 diabetes mellitus in Guangxi, China: a cross-sectional study

in Diabetes Nephropathy

Yelan Huang
Jingfeng Chen
Chaoqun Bai
Xiaoxue Lei
Yanping Zhang
Guifen Fu

Frontiers in Clinical Diabetes and Healthcare

doi 10.3389/fcdhc.2026.1706901

193 views

Original Research

Published on 27 Feb 2026

Establishment and validation of an interpretable machine learning-based predictive model for risk of post-PCI in-hospital heart failure in AIHD patients

in Coronary Artery Disease

Xinying Zhao
Zhihang Wang
Qiqi Yang
Huiqi Liu
Yigen Li
Xi Ye

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1785285

Original Research

Published on 27 Feb 2026

Development and external validation of a machine learning model for predicting in-hospital mortality in ICU patients with diabetic kidney disease: a study utilizing the MIMIC database and a Chinese cohort

in Clinical Diabetes

YuNan Han
RuMeng Mao
ChengYue Xiong
YongXiang Wang
Lin Li
HongLian Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1699647

Articles

Generation and preclinical characterization of a novel bispecific CD19-TCRgammadelta antibody for the treatment of B cell acute lymphoblastic leukemia

Multimodal therapeutic efficacy assessment of vagus nerve stimulation in stroke: integrated application of imaging, electrophysiological, and behavioral indicators

Advances in the immunosuppression of porcine reproductive and respiratory syndrome virus

Dynamic TyG trajectories cumulative TyG burden are associated with in-hospital mortality in acute brain injury: a multicenter interpretable machine-learning analysis

Dual PD-1 and CTLA-4 targeting in endometrial carcinoma: integrating efficacy, toxicity, and biomarkers into clinical practice

Reflections on prevention and treatment of post-thyroidectomy hypoparathyroidism: current management approaches and future prospects

Milena Auretta Rosso first female Italian neurosurgeon

Case Report: Morphologically striking eruptive xanthomas with lobulated papules: a sentinel sign of severe metabolic dysregulation

GFTrans: an on-the-fly static analysis framework for code performance profiling

Impact of biliary fungal contamination on outcomes after pancreaticoduodenectomy for pancreatic cancer

Moisture-driven shifts in the fermentation characteristics and microbial community of alfalfa silage treated with different additives

Dysbiosis of intestinal microbiota in patients with neuromyelitis optica spectrum disorders

Combination of single-cell and bulk RNA-seq reveals changes in the immune landscape in osteomyelitis

Prevalence and associated factors of diabetic kidney disease among rural patients with type 2 diabetes mellitus in Guangxi, China: a cross-sectional study

Establishment and validation of an interpretable machine learning-based predictive model for risk of post-PCI in-hospital heart failure in AIHD patients

Development and external validation of a machine learning model for predicting in-hospital mortality in ICU patients with diabetic kidney disease: a study utilizing the MIMIC database and a Chinese cohort