Development and External Validation of a Machine Learning Model for Predicting In-Hospital Mortality in ICU Patients with Diabetic Kidney Disease: A Study Utilizing the MIMIC Database and a Chinese Cohort

YuNan Han¹RuMeng Mao¹ChengYue Xiong²YongXiang Wang²Lin Li^1*HongLian Wang^1*

• ¹The First Affiliated Hospital of Yangtze University, Jingzhou, China
• ²Yangtze University, Jingzhou, China

Background: Patients with diabetic kidney disease (DKD) admitted to the intensive care unit (ICU) face an exceptionally high risk of in-hospital mortality. Currently, effective tools for their early risk stratification are critically lacking. Therefore, this study aimed to develop and externally validate an interpretable machine learning (ML) model for predicting in-hospital mortality in this high-risk ICU-DKD patient population. Methods: This retrospective cohort study involved developing and evaluating eight ML algorithms. Model performance was rigorously assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). SHapley Additive exPlanations (SHAP) provided model interpretability. Data from DKD patients with ≥24-hour ICU stays were extracted from the MIMIC-IV database (n=3,403) for model development. An independent external validation cohort (n=260) was collected from the First Affiliated Hospital of Yangtze University (YTU-ICU). The primary outcome was in-hospital mortality. Lasso regression identified key predictors. Model evaluation focused on the area under the ROC curve (AUROC), calibration, and net clinical benefit. Results: Ten features were selected for model development. Among the tested algorithms, XGBoost demonstrated superior predictive performance, achieving an AUROC of 0.738 (internal validation) and 0.746 (external validation), with corresponding accuracies of 72.18% and 72.69%. SHAP analysis highlighted respiratory failure, lymphocyte count, SOFA score, RDW, age, and SAPS II as the six most important predictors. Conclusions: The developed XGBoost model demonstrates good predictive performance for in-hospital mortality in ICU-DKD patients, exhibiting satisfactory generalizability and interpretability. This tool supports early risk stratification and facilitates personalized treatment strategies in critical care settings.