REVIEW article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Reflections on Prevention and Treatment of Post-thyroidectomy 1 Hypoparathyroidism: Current Management Approaches and Future 2 Prospects
Provisionally accepted
- Affiliated Hospital of Zunyi Medical University, Zunyi, China
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Postoperative hypoparathyroidism (hypoPT) is one of the predominant and severe 9 complications of thyroid surgery. This condition manifests as suboptimal circulatory 10 levels of parathyroid hormone (PTH), engendering multifaceted systemic perturbations. 11 This comprehensive review elucidates the underlying pathophysiological mechanisms 12 and clinical presentations associated with hypoparathyroidism. Moreover, 13 methodologies for the precise recognition and preservation (naked eye, near-infrared 14 autofluorescence, indocyanine green, and nanocarbon) of the parathyroid gland during 15 thyroid surgery have been explored, along with recent therapeutic innovations 16 (palopegteriparatide and parathyroid organoids). Finally, this review prospects and 17 interventions via organoids are contemplated. The aim of the literature is to recapitulate 18 the knowledge and the gaps in this field, increasing awareness of postoperative 19 hypoparathyroidism , and improve the prognosis for patients afflicted with 20 hypoparathyroidism.
Keywords: Hypocalcemia, Management, Organoid, Postsurgical hypoparathyroidism, Thyroid Surgery, Treatment
Received: 15 Dec 2025; Accepted: 11 Feb 2026.
Copyright: © 2026 Li, Hu, Ma, Feng, Zhang, Zhu, Hu, Han and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Taolang Li
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