Drug Design And Development | List of Frontiers open access articles

Original Research

Published on 03 Oct 2025

Development and validation of a lactate and procalcitonin-based nomogram model for predicting prognosis in ICU sepsis patients

in Emergency Health Services

Kai-Xi Tian
Jie-Xuan Dong
Juan Du
Xu-Bing Huang
Yi Liu

Frontiers in Disaster and Emergency Medicine

doi 10.3389/femer.2025.1612093

171 views

Original Research

Published on 03 Oct 2025

Efficacy and safety of the third-generation tyrosine kinase inhibitor Olverembatinib in relapsed and persistent minimal residual disease positive Philadelphia chromosome-positive acute lymphoblastic leukemia patients

in Hematology

Xinwen Jiang
Minran Zhou
Junjie Ma
Qingli Ji
Xiaoqing Li
Sai Ma
Chunyan Chen

Frontiers in Medicine

doi 10.3389/fmed.2025.1662512

304 views

Original Research

Published on 03 Oct 2025

Bilateral strength balance of knee extensor and flexor muscles in female soccer players

in Exercise Physiology

Oscar Andrades-Ramírez
David Ulloa-Díaz
Luis Romero-Vera
Bryan Alfaro-Castillo
Gustavo Muñoz-Bustos
Carlos Jorquera-Aguilera
Claudio Carvajal-Parodi
Luis-Javier Chirosa-Ríos

Frontiers in Physiology

doi 10.3389/fphys.2025.1681804

265 views

Original Research

Published on 03 Oct 2025

DHCLHAM: microbe-drug interaction prediction based on dual-hypergraph contrastive learning framework with hierarchical attention mechanism

in Microbial Symbioses

Hailong Hu
Cong Nie

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1657431

700 views

Original Research

Published on 03 Oct 2025

Exploring chamazulene as a novel therapeutic agent for breast cancer in silico and in vitro: apoptosis induction, cell cycle regulation, and antimetastatic effects

in Pharmacology of Anti-Cancer Drugs

Liang Yao
Wanfu Wang
Bo Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680615

484 views

Policy and Practice Reviews

Published on 03 Oct 2025

Can international investment agreements protect investments in non-territorial waters?—institutional foundations, jurisdictional analysis, and pathways for improvement

in Marine Pollution

Xingyi Duan
Ziheng Liu

Frontiers in Marine Science

doi 10.3389/fmars.2025.1654756

187 views

Original Research

Published on 03 Oct 2025

The perceived impact of artificial intelligence on academic learning

in AI for Human Learning and Behavior Change

Mariana Dogaru
Olivia Pisică
Cosmin-Ștefan Popa
Andrei-Adrian Răgman
Ilinca-Roxana Tololoi

Frontiers in Artificial Intelligence

doi 10.3389/frai.2025.1611183

858 views

Original Research

Published on 03 Oct 2025

Predictive effect of sustainable dietary and literacy patterns on metabolic syndrome and diabetes risk in Turkish adults: Mediterranean diet, sustainable healthy eating behaviors, and sustainable food literacy perspective

in Family Medicine and Primary Care

Serap İncedal Irgat
Hande Bakırhan
Yunus Emre Bakırhan

Frontiers in Medicine

doi 10.3389/fmed.2025.1693180

217 views

Review

Published on 03 Oct 2025

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

in Signaling

Yanxian Zhang
Lili Yao
Yongmei Lyu
Zhuqi Tang
Xiaoyu Liu
Xuchu Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631678

256 views

Opinion

Published on 03 Oct 2025

Stromal cells unifying the pathology of acute and chronic skeletal muscle injury – clue for novel biomaterials

in Biomaterials

Xianglong Liu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1684310

279 views

Review

Published on 03 Oct 2025

ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Tianzhen Wang
Liyun Duan
Beiying Zhao
Jingbin Zhang
Yongjiang Yu
Jinyue Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639196

154 views

Review

Published on 03 Oct 2025

From crops to clinic: the impact of dual azole use on antifungal resistance in Candida and Candida associated yeasts

in Infectious Agents and Disease

Jessica C. Allison
Edel M. Hyland

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1656723

893 views

Original Research

Published on 03 Oct 2025

Knowledge, attitudes, and practices regarding fertility preservation among women of childbearing age in southern China: a cross-sectional study

in Public Health Education and Promotion

Yan Zhang
Juan An
Fanglan Hua
Yanhong Wei
Fanglian Shu

Frontiers in Public Health

doi 10.3389/fpubh.2025.1612784

135 views

Mini Review

Published on 03 Oct 2025

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

in Pain Mechanisms and Modulators

Min Ma
Yue Zhang
Kunming Tao
Zhijie Lu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1675814

622 views

Review

Published on 03 Oct 2025

Optimization of production strategies for African indigenous trees: a case study of tree growers and sellers of Dovyalis caffra (Kei apple) from Eastern Cape of South Africa

in Food Characterization

M. Mfini
C. P. Laubscher
H. Witbooi

Frontiers in Food Science and Technology

doi 10.3389/frfst.2025.1631026

221 views

Review

Published on 03 Oct 2025

Overcoming resistance to PD-1 and CTLA-4 blockade mechanisms and therapeutic strategies

in Cancer Immunity and Immunotherapy

Xiaodong Wang
Jing He
Gouping Ding
Yixuan Tang
Qianqian Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688699

134 views

Articles

Development and validation of a lactate and procalcitonin-based nomogram model for predicting prognosis in ICU sepsis patients

Efficacy and safety of the third-generation tyrosine kinase inhibitor Olverembatinib in relapsed and persistent minimal residual disease positive Philadelphia chromosome-positive acute lymphoblastic leukemia patients

Bilateral strength balance of knee extensor and flexor muscles in female soccer players

DHCLHAM: microbe-drug interaction prediction based on dual-hypergraph contrastive learning framework with hierarchical attention mechanism

Exploring chamazulene as a novel therapeutic agent for breast cancer in silico and in vitro: apoptosis induction, cell cycle regulation, and antimetastatic effects

Can international investment agreements protect investments in non-territorial waters?—institutional foundations, jurisdictional analysis, and pathways for improvement

The perceived impact of artificial intelligence on academic learning

Predictive effect of sustainable dietary and literacy patterns on metabolic syndrome and diabetes risk in Turkish adults: Mediterranean diet, sustainable healthy eating behaviors, and sustainable food literacy perspective

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

Stromal cells unifying the pathology of acute and chronic skeletal muscle injury – clue for novel biomaterials

ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets

From crops to clinic: the impact of dual azole use on antifungal resistance in Candida and Candida associated yeasts

Knowledge, attitudes, and practices regarding fertility preservation among women of childbearing age in southern China: a cross-sectional study

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

Optimization of production strategies for African indigenous trees: a case study of tree growers and sellers of Dovyalis caffra (Kei apple) from Eastern Cape of South Africa

Overcoming resistance to PD-1 and CTLA-4 blockade mechanisms and therapeutic strategies