ORIGINAL RESEARCH article
Front. Disaster Emerg. Med.
Sec. Emergency Health Services
Volume 3 - 2025 | doi: 10.3389/femer.2025.1612093
Development and Validation of a Lactate and Procalcitonin-Based Nomogram Model for Predicting Prognosis in ICU Sepsis Patients
Provisionally accepted
- 1Baoshan Traditional Chinese Medicine Hospital, China, Baoshan Traditional Chinese Medicine Hospital, Baoshan City, Czechia
- 2First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin, China
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ABSTRACT Objective: A nomogram model for predicting the prognosis of patients with sepsis in the intensive care unit (ICU) was developed based on lactate and procalcitonin (PCT) and externally validated. Methods: From the anonymous medical database of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 55 patients with sepsis admitted to the ICU of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine were retrospectively collected. Demographic data, admission leukocyte count, lactate, PCT, and other clinical parameters were collected. Based on 28-day outcomes, patients were stratified into survival and mortality groups. Independent prognostic risk factors were identified In reviewthrough multivariate logistic regression analysis, and a nomogram prediction model was subsequently developed and internally validated. From the anonymous medical database of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, an additional 45 ICU sepsis patients were collected to form an independent cohort for external validation.
Keywords: Sepsis, Lactic Acid, Procalcitonin, Line chart prediction model, External verification, prognosis
Received: 15 Apr 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Tian, Dong, Du, Huang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Liu, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, 300193, Tianjin, China
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