Generalized Pustular Psoriasis | List of Frontiers open access articles

Case Report

Published on 15 May 2025

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xin-Yi Hou
Hai-Lu Xiao
Jing-Yu Wang
Jin Zhang
Bo Ren
Chu-chu Niu
Fei-Fei Liu
Bin Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563553

2,875 views

Case Report

Published on 17 Feb 2025

Case report: Efficacy of tofacitinib in the treatment of generalized pustular psoriasis

in Dermatology

Xian Wang
Mei Zhang
Ming He
Ting Tang

Frontiers in Medicine

doi 10.3389/fmed.2025.1518583

3,820 views
3 citations

Case Report

Published on 10 Jan 2023

Case report: Infantile generalized pustular psoriasis with IL36RN and CARD14 gene mutations

in Genetics of Common and Rare Diseases

Xinyun Tong
Yang Li
Xianfa Tang
Yantao Ding
Yao Sun
Liyun Zheng
Yulong Pan
Shengxiu Liu

Frontiers in Genetics

doi 10.3389/fgene.2022.1035037

6,051 views
6 citations

Original Research

Published on 08 Sep 2021

Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response

in Molecular Innate Immunity

Ning Yu
Chen Peng
Wenjuan Chen
Ziwen Sun
Jianfeng Zheng
Shujie Zhang
Yangfeng Ding
Yuling Shi

Frontiers in Immunology

doi 10.3389/fimmu.2021.739514

7,633 views
19 citations

Case Report

Published on 20 Mar 2024

Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Ghaith Adi
Mohammed Rami Shaath
Kareem Adi
Zaki Obaid
Egab Aldosari
Faten Ahmed AlKateb

Frontiers in Immunology

doi 10.3389/fimmu.2024.1337799

4,742 views
3 citations

Case Report

Published on 08 Dec 2022

Case report: Successful treatment of acute generalized pustular psoriasis of puerperium with secukinumab

in Dermatology

Gao Xue
Ma Lili
Fang Yimiao
Wu Miao
Yang Xiaohong
Wang Dongmei

Frontiers in Medicine

doi 10.3389/fmed.2022.1072039

5,250 views
7 citations

Case Report

Published on 19 Mar 2024

Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Mingdan Zhao
Fujun Huang
Lei Tang
Xun Zhou
Miao Zhang
Mengxue Liao
Lirong Liu
Mengya Huang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1354578

3,755 views
2 citations

Review

Published on 22 Jul 2024

Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Eran C. Gwillim
Anna J. Nichols

Frontiers in Immunology

doi 10.3389/fimmu.2024.1359481

8,252 views
13 citations

Case Report

Published on 14 Nov 2025

Successful treatment with secukinumab in a 4-month-old infant with severe generalized pustular psoriasis: a case report

in Dermatology

Long Wang
Yirong Li
Chen Li
Lizhen Zhang
Lequ Zeng

Frontiers in Medicine

doi 10.3389/fmed.2025.1713628

1,256 views

Original Research

Published on 11 Dec 2023

IL-17A-driven psoriasis is critically dependent on IL-36 signaling

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Berenice Fischer
Tanja Kübelbeck
Antonia Kolb
Julia Ringen
Ari Waisman
Miriam Wittmann
Susanne Karbach
Stephan Marcus Kölsch
Daniela Kramer

Frontiers in Immunology

doi 10.3389/fimmu.2023.1256133

9,073 views
20 citations

Case Report

Published on 13 Oct 2025

Case Report: Hydroxychloroquine-induced generalized pustular psoriasis in a pediatric patient with systemic lupus erythematosus

in Pediatric Rheumatology

Xue Wang
Linlin Dong
Hui Qiu
Yihuai Xu
Linxiaoyu Kong
Weiran Zhou

Frontiers in Pediatrics

doi 10.3389/fped.2025.1652376

2,524 views
1 citation

Case Report

Published on 29 Aug 2025

Combination therapy with spesolimab and apremilast for refractory generalized pustular psoriasis: a case report

in Dermatology

Yuwei Li
Zhenyu Li
Xinhong Hu
Tianyu Cao
Ling Liu

Frontiers in Medicine

doi 10.3389/fmed.2025.1668675

2,381 views

Case Report

Accepted on 11 May 2026

Breaking the Barrier: Oral Tacrolimus plus Apremilast Rescues Acute Generalized Pustular Psoriasis with Severe Comorbidities—A Case Report

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Lei Tang
Yiman He
Ze Yun Qiao
Xun Zhou
Pingsheng Hao

Frontiers in Immunology

Case Report

Published on 17 Mar 2026

Pustular psoriasis flare following COVID-19 infection: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Eri Ohta
Etsuko Okada
Yu Sawada

Frontiers in Immunology

doi 10.3389/fimmu.2026.1740000

761 views

Review

Published on 09 Aug 2024

Clinical efficacy and safety of secukinumab in the treatment of generalized pustular psoriasis in the pediatric population: a systematic review of the literature

in Dermatology

Kebo Wei
Ping Li
Xin He
Dongyue Yang
Jing Lang
Lingyao Lai
Min Xiao

Frontiers in Medicine

doi 10.3389/fmed.2024.1377381

4,092 views
4 citations

Case Report

Published on 17 Apr 2026

RSV infection-associated pediatric generalized pustular psoriasis with innate immune activation: a case report

in Inflammation

Xiaoyu Zhou
Ran An
Pengting Qu
Qianwen Wang
Wenkang Cheng
Siyan Liu
Junhong Zhao
Haixia Jing

Frontiers in Immunology

doi 10.3389/fimmu.2026.1808692

586 views

Articles

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights

Case report: Efficacy of tofacitinib in the treatment of generalized pustular psoriasis

Case report: Infantile generalized pustular psoriasis with IL36RN and CARD14 gene mutations

Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response

Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report

Case report: Successful treatment of acute generalized pustular psoriasis of puerperium with secukinumab

Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus

Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval

Successful treatment with secukinumab in a 4-month-old infant with severe generalized pustular psoriasis: a case report

IL-17A-driven psoriasis is critically dependent on IL-36 signaling

Case Report: Hydroxychloroquine-induced generalized pustular psoriasis in a pediatric patient with systemic lupus erythematosus

Combination therapy with spesolimab and apremilast for refractory generalized pustular psoriasis: a case report

Breaking the Barrier: Oral Tacrolimus plus Apremilast Rescues Acute Generalized Pustular Psoriasis with Severe Comorbidities—A Case Report

Pustular psoriasis flare following COVID-19 infection: a case report and literature review

Clinical efficacy and safety of secukinumab in the treatment of generalized pustular psoriasis in the pediatric population: a systematic review of the literature

RSV infection-associated pediatric generalized pustular psoriasis with innate immune activation: a case report