Guided Play | List of Frontiers open access articles

Original Research

Published on 19 Nov 2025

Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling

in Cancer Molecular Targets and Therapeutics

Yujie Shi
Peijia Niu
Qiong Cheng
Lexia Chen
Yahan Weng
Xiaohe Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1631415

519 views

Original Research

Published on 19 Nov 2025

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

in Brain Disease Mechanisms

Lisa Bergmeister
Carolina Doerrier
Barbara Fogli
Tímea Komlódi
Amrei Fischer
Kerstin Springer
Christoph Schwarzer
Erich Gnaiger

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1628567

849 views

Original Research

Published on 19 Nov 2025

Matrix-biased excitatory and inhibitory inputs to the striatum involving external segment of the globus pallidus

in Cellular Neurophysiology

Fuyuki Karube
Kenta Kobayashi
Fumino Fujiyama

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1706469

390 views

Original Research

Published on 19 Nov 2025

Hydrocarbon charging processes of deep fractured-vuggy dolomite reservoirs in the Ediacaran Dengying Formation, Southern Sichuan Basin, SW China

in Economic Geology

Hongxiang Jin

Frontiers in Earth Science

doi 10.3389/feart.2025.1710366

366 views

Original Research

Published on 19 Nov 2025

Establishment and validation of a prognostic model for nasopharyngeal carcinoma patients based on partial response rates

in Head and Neck Cancer

Fujue Wang
Qiao Yang
Dong Yang
Chuangjie Cao
Xinghua Chen
Jiancheng Ning
Tianyu Wu
Wei Zhou
Zhe Fang
Pian Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1705634

271 views

Original Research

Published on 19 Nov 2025

Enhancing climate resilience of smallholder farmers through conservation agriculture in the southern highlands of Tanzania

in Climate-Smart Food Systems

Adolph Katunzi
Ndabhemeye Mlengera
Marco Mng’ong’o
Benodictor Mwamlima
Baraka Mvile
Johnson Mtama
Revina Lukasumbusa

Frontiers in Sustainable Food Systems

doi 10.3389/fsufs.2025.1706205

921 views

Original Research

Published on 19 Nov 2025

Imbalanced nutrition and increased dietary inflammatory index in children with autism spectrum disorder: associations with neurodevelopmental disorders

in Nutrition, Psychology and Brain Health

Jing Shen
Junqiao You
Wenjing Wang
Wenli Yang
Wenli Zhao
Jianan Zhao
Huini Ding
Yuandi Xi
Hongmei Huang

Frontiers in Nutrition

doi 10.3389/fnut.2025.1705682

424 views

Original Research

Published on 19 Nov 2025

Rainbows in my ears—Synesthetic color perception with partial-reduced and morphed musical instrument timbres

in Performance Science

Christoph Reuter
Isabella Czedik-Eysenberg
Sarah Ambros
Saleh Siddiq
Solange Glasser
Jamie Ward
Jörg Jewanski

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1697918

1,308 views

Perspective

Published on 19 Nov 2025

Regulatory T cell transdifferentiation as a driver of obesity and diabetes

in Cytokines and Soluble Mediators in Immunity

Acelya Yilmazer
Dimitra Maria Zevla
Karsten Kretschmer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698285

245 views

Case Report

Published on 19 Nov 2025

Rare MSI-H hepatoid adenocarcinoma of the colon with BRAF V600E mutation achieving long-term disease-free survival after adjuvant envafolimab: a case report

in Cancer Immunity and Immunotherapy

Shaoqing Fan
Qingyu Meng
Zeming Zhao
Wenbo Niu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698410

353 views

Original Research

Published on 19 Nov 2025

Comparative proteomics and micro-RNA analysis of skeletal muscle cell small extracellular vesicles - Unique profiles in cells from severely obese individuals with type 2 diabetes versus normal glucose tolerance

in Striated Muscle Physiology

Stian Forstrøm Christiansen
Kari Bente Foss Haug
Misbah Hussain
Abdille Hussein
Berit Sletbakk Brusletto
Reidun Øvstebø
Oliwia Witczak
Vigdis Aas

Frontiers in Physiology

doi 10.3389/fphys.2025.1696916

349 views

Mini Review

Published on 19 Nov 2025

The “double-edged sword” effect of cytokines in cancer: coexisting opportunities and challenges

in Cancer Immunity and Immunotherapy

Xuan Yin
Wangzheqi Zhang
Guanhua Wang
Yawei Liu
Bing Dai
Liping Yue

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701405

261 views

Original Research

Published on 19 Nov 2025

Exudates of dominant plants regulate rhizospheric soil total and available heavy metals and facilitates natural restoration succession in an abandoned metal mining area

in Toxicology, Pollution and the Environment

Xiaoya Yu
Ting Li
Xiaoni Wu
Chang’e Liu
Shiyu Li
Shuxian Peng
Sichen Wang
Luoqi Zhao
Changqun Duan

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1698742

618 views

Original Research

Published on 19 Nov 2025

Do generative models learn rare generative factors?

in Machine Learning and Artificial Intelligence

Fasih Haider
Edward Moroshko
Yuyang Xue
Sotirios A. Tsaftaris

Frontiers in Artificial Intelligence

doi 10.3389/frai.2025.1697139

514 views

Case Report

Published on 19 Nov 2025

Case Report of a patient with Madelung’s disease combined with alcoholic liver disease and liver cirrhosis

in Hepatobiliary Diseases

Ziming Gu
Yi Hao
Junwei Duan
Keqi Zhao

Frontiers in Medicine

doi 10.3389/fmed.2025.1695921

249 views

Original Research

Published on 19 Nov 2025

Examining the nonlinear effects of multidimensional land use efficiency on ecological resilience using the XGBoost-SHAP and GTWR model in Guangdong province

in Land Use Dynamics

Tian Liang
Jinrui Zhan
Yongjun Su
Weifeng Deng

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1697381

727 views

Articles

Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

Matrix-biased excitatory and inhibitory inputs to the striatum involving external segment of the globus pallidus

Hydrocarbon charging processes of deep fractured-vuggy dolomite reservoirs in the Ediacaran Dengying Formation, Southern Sichuan Basin, SW China

Establishment and validation of a prognostic model for nasopharyngeal carcinoma patients based on partial response rates

Enhancing climate resilience of smallholder farmers through conservation agriculture in the southern highlands of Tanzania

Imbalanced nutrition and increased dietary inflammatory index in children with autism spectrum disorder: associations with neurodevelopmental disorders

Rainbows in my ears—Synesthetic color perception with partial-reduced and morphed musical instrument timbres

Regulatory T cell transdifferentiation as a driver of obesity and diabetes

Rare MSI-H hepatoid adenocarcinoma of the colon with BRAF V600E mutation achieving long-term disease-free survival after adjuvant envafolimab: a case report

Comparative proteomics and micro-RNA analysis of skeletal muscle cell small extracellular vesicles - Unique profiles in cells from severely obese individuals with type 2 diabetes versus normal glucose tolerance

The “double-edged sword” effect of cytokines in cancer: coexisting opportunities and challenges

Exudates of dominant plants regulate rhizospheric soil total and available heavy metals and facilitates natural restoration succession in an abandoned metal mining area

Do generative models learn rare generative factors?

Case Report of a patient with Madelung’s disease combined with alcoholic liver disease and liver cirrhosis

Examining the nonlinear effects of multidimensional land use efficiency on ecological resilience using the XGBoost-SHAP and GTWR model in Guangdong province