Huangkui | List of Frontiers open access articles

Review

Published on 10 Dec 2025

Therapeutic potential of Abelmoschus manihot: mechanisms of action and clinical use in traditional Chinese medicine formulas

in Ethnopharmacology

Chu Xue
Haitao Ge
Yaru Liu
Yan Zhao
Wenjie Huang
Zhaowen Lu
Qiuhui Ye
Xiaoli Chen
Zhengyu Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709530

919 views

Original Research

Published on 24 Feb 2026

Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects

in Renal Pharmacology

Yihong Yu
Haitao Tang
Nan Li
Haitao Ge
Jie Wu
Harvest F. Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1775173

244 views

Review

Published on 04 Nov 2021

New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

in Renal Pharmacology

Minghai Shao
Chaoyang Ye
George Bayliss
Shougang Zhuang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.774414

13,161 views
40 citations

Original Research

Published on 01 Aug 2023

Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys

in Ethnopharmacology

Hongmei Yu
Mei Wang
Jingshi Yu
Haitao Tang
Qing Xu
Ning Cheng
Xiaoxiao Luo
Yurong Wang
Haitao Ge
Lei Qiang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1215996

4,241 views
11 citations

Original Research

Published on 03 Jul 2020

Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways

in Ethnopharmacology

Li-fei Gu
Hai-tao Ge
Lei Zhao
Yu-jing Wang
Fan Zhang
Hai-tao Tang
Zheng-yu Cao
Bo-yang Yu
Cheng-zhi Chai

Frontiers in Pharmacology

doi 10.3389/fphar.2020.00996

7,496 views
22 citations

Original Research

Published on 28 Apr 2025

Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis

in Renal Pharmacology

Chang Qing Wen
Jia Zou
Jia Xuan Li
Fu Jiang Wang
Hai Tao Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560420

2,815 views
3 citations

Review

Published on 30 Jul 2025

Research progress in the treatment of lipid metabolism disorder in patients with diabetic kidney disease by the integrated traditional Chinese and Western medicine

in Renal Endocrinology

Lingli Sheng
Ziyi Cao
Lin Wang
Youhua Xu
Dingkun Gui

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1631312

6,301 views
1 citation

Original Research

Published on 23 May 2018

Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy

in Ethnopharmacology

Wei Wu
Wei Hu
Wen-Bei Han
Ying-Lu Liu
Yue Tu
Hai-Ming Yang
Qi-Jun Fang
Mo-Yi Zhou
Zi-Yue Wan
Ren-Mao Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00443

8,964 views
69 citations

Original Research

Published on 22 Aug 2022

Huangkui lianchang decoction attenuates experimental colitis by inhibiting the NF-κB pathway and autophagy

in Ethnopharmacology

Xudong Cheng
Jun Du
Qing Zhou
Bensheng Wu
Haodong Wang
Zhizhong Xu
Shuguang Zhen
Jieyu Jiang
Xiaopeng Wang
Zongqi He

Frontiers in Pharmacology

doi 10.3389/fphar.2022.951558

6,037 views
8 citations

Review

Published on 25 Feb 2026

Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations

in Renal Endocrinology

Wencan Li
Chaoqi Lei
Qinxuan Wu
Keqian Chen
Zheng Liu
Qichang Xing
Xiang Liu
Jiani Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1792000

204 views

Original Research

Published on 30 Apr 2025

Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway

in Renal Pharmacology

Jiayu Su
Ying Zhang
Xuan Wang
Xiaochao Hu
Ke Zhou
Huimin Zhu
Ehu Liu
Shijia Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1535352

4,078 views
2 citations

Original Research

Published on 28 Jan 2026

Total flavonoids from Abelmoschus manihot (L.) improve diabetes nephropathy by regulating the gut–kidney axis

in Nephrology

Hongmei Yu
Yuanxin Liu
Harvest F. Gu
Wei Tang
Nan Li

Frontiers in Medicine

doi 10.3389/fmed.2025.1693643

666 views

Original Research

Published on 08 Jan 2024

Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy

in Ethnopharmacology

Zhipeng Diao
Hongmei Yu
Yapeng Wu
Yuanbo Sun
Haitao Tang
Mei Wang
Nan Li
Haitao Ge
Jianguo Sun
Harvest F. Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1290868

4,676 views
20 citations

Original Research

Published on 28 Oct 2024

Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis

in Renal Pharmacology

Hongmei Yu
Haitao Tang
Rengui Saxu
Yuhui Song
Xu Cui
Jingjing Xu
Nan Li
Siyuan Cui
Haitao Ge
Wei Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1424968

4,633 views
6 citations

Original Research

Published on 04 Aug 2025

Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification

in Renal Pharmacology

Xuanke Liu
Chunjiang Zhang
YanJie Fu
JingJing Dai
Jiaying Lu
Gang Liu
Xiaoping Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625286

4,324 views
3 citations

Systematic Review

Published on 22 Aug 2022

Clinical efficacy, safety, and cost of nine Chinese patent medicines combined with ACEI/ARB in the treatment of early diabetic kidney disease: A network meta-analysis

in Ethnopharmacology

Jiarong Liu
Xuehan Zhang
Gaosi Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.939488

10,227 views
13 citations

Articles

Therapeutic potential of Abelmoschus manihot: mechanisms of action and clinical use in traditional Chinese medicine formulas

Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects

New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys

Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways

Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis

Research progress in the treatment of lipid metabolism disorder in patients with diabetic kidney disease by the integrated traditional Chinese and Western medicine

Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy

Huangkui lianchang decoction attenuates experimental colitis by inhibiting the NF-κB pathway and autophagy

Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations

Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway

Total flavonoids from Abelmoschus manihot (L.) improve diabetes nephropathy by regulating the gut–kidney axis

Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy

Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis

Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification

Clinical efficacy, safety, and cost of nine Chinese patent medicines combined with ACEI/ARB in the treatment of early diabetic kidney disease: A network meta-analysis