In Silico Experiments | List of Frontiers open access articles

Original Research

Published on 31 May 2012

Arrhythmogenic Right Ventricular Cardiomyopathy: Considerations from in Silico Experiments

in Cardiac Electrophysiology

Ronald Wilders

Frontiers in Physiology

doi 10.3389/fphys.2012.00168

4,962 views
16 citations

Review

Published on 10 May 2022

A Review of Healthy and Fibrotic Myocardium Microstructure Modeling and Corresponding Intracardiac Electrograms

in Cardiac Electrophysiology

Jorge Sánchez
Axel Loewe

Frontiers in Physiology

doi 10.3389/fphys.2022.908069

4,526 views
11 citations

Original Research

Published on 19 Mar 2013

A Model of Dendritic Cell Therapy for Melanoma

in Molecular and Cellular Oncology

Ami Radunskaya
Lisette de Pillis
Angela Gallegos

Frontiers in Oncology

doi 10.3389/fonc.2013.00056

9,424 views
64 citations

Original Research

Published on 30 Mar 2017

Genome-Scale Reconstruction of the Metabolic Network in Oenococcus oeni to Assess Wine Malolactic Fermentation

in Food Microbiology

Sebastián N. Mendoza
Pablo M. Cañón
Ángela Contreras
Magdalena Ribbeck
Eduardo Agosín

Frontiers in Microbiology

doi 10.3389/fmicb.2017.00534

9,773 views
47 citations

Methods

Published on 04 Nov 2025

A motion capture protocol for the kinematic analysis of transfemoral and transtibial sprinters

in Biomechanics

Roberto Di Marco
Samira G. Breban
Giuseppe Zullo
Francesca Gariboldi
Mattia Scapinello
Gian Luca Migliore
Nicola Petrone
Andrea G. Cutti

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1655295

1,674 views

Original Research

Published on 03 Feb 2026

Computational physiological modeling for lung-specific ventilation and perfusion management in ex vivo lung perfusion

in Computational Physiology and Medicine

Daan Imholz
Sue A. Braithwaite
Paul Blankman
Eline Oppersma
Frans H. C. de Jongh
Linda M. de Heer
Bart Luijk
Wolfgang F. F. A. Buhre
Dirk W. Donker
Lex M. van Loon

Frontiers in Physiology

doi 10.3389/fphys.2025.1724724

1,013 views

Mini Review

Published on 17 Aug 2021

Understanding the Role of Endothelial Glycocalyx in Mechanotransduction via Computational Simulation: A Mini Review

in Signaling

Xi Zhuo Jiang
Kai H. Luo
Yiannis Ventikos

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.732815

4,293 views
11 citations

Original Research

Published on 12 Jul 2022

Mapping CAR T-Cell Design Space Using Agent-Based Models

in Biological Modeling and Simulation

Alexis N. Prybutok
Jessica S. Yu
Joshua N. Leonard
Neda Bagheri

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.849363

11,854 views
26 citations

Original Research

Published on 06 Jul 2016

Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine

in Computational Genomics

Alexis Pietak
Michael Levin

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2016.00055

17,979 views
81 citations

Original Research

Published on 04 Nov 2021

In Silico and In Vivo: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model

in Industrial Biotechnology

Hammad Ahmed
Mahtab Ahmad Khan
Syed Awais Ali Zaidi
Sajjad Muhammad

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.754952

8,869 views
29 citations

Technology and Code

Published on 20 Jan 2021

BCNNM: A Framework for in silico Neural Tissue Development Modeling

Dmitrii V. Bozhko
Georgii K. Galumov
Aleksandr I. Polovian
Sofiia M. Kolchanova
Vladislav O. Myrov
Viktoriia A. Stelmakh
Helgi B. Schiöth

Frontiers in Computational Neuroscience

doi 10.3389/fncom.2020.588224

8,736 views
4 citations

Review

Published on 07 Aug 2020

DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications?

in Translational Pharmacology

Inés Valencia
Concepción Peiró
Óscar Lorenzo
Carlos F. Sánchez-Ferrer
Jürgen Eckel
Tania Romacho

Frontiers in Pharmacology

doi 10.3389/fphar.2020.01161

20,301 views
91 citations

Methods

Published on 03 Feb 2012

In silico Models of Alcohol Dependence and Treatment

in Systems Biology Archive

Boris Kovatchev
Marc Breton

Frontiers in Psychiatry

doi 10.3389/fpsyt.2012.00004

8,243 views
6 citations

Original Research

Published on 09 Oct 2020

A Middle-Out Modeling Strategy to Extend a Colon Cancer Logical Model Improves Drug Synergy Predictions in Epithelial-Derived Cancer Cell Lines

in Biological Modeling and Simulation

Eirini Tsirvouli
Vasundra Touré
Barbara Niederdorfer
Miguel Vázquez
Åsmund Flobak
Martin Kuiper

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.502573

7,297 views
18 citations

Review

Published on 20 Oct 2025

Evaluating the combined efficacy of Telisotuzumab Vedotin and artificial intelligence in the treatment of non-squamous non-small cell lung cancer: a narrative review focusing on pharmaceutical and technical insights

in Thoracic Oncology

Syeda Huda Fatima
Syeda Jazilah Faisal
Syeda Verisha Batool
Mehak Faisal
Talha Aamir
Zain Ul Abideen Shahid
Raghabendra Kumar Mahato

Frontiers in Oncology

doi 10.3389/fonc.2025.1673586

3,449 views

Original Research

Published on 12 Dec 2023

Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes

in Cardiac Electrophysiology

Arie O. Verkerk
Ronald Wilders

Frontiers in Physiology

doi 10.3389/fphys.2023.1326160

4,057 views
15 citations

Articles

Arrhythmogenic Right Ventricular Cardiomyopathy: Considerations from in Silico Experiments

A Review of Healthy and Fibrotic Myocardium Microstructure Modeling and Corresponding Intracardiac Electrograms

A Model of Dendritic Cell Therapy for Melanoma

Genome-Scale Reconstruction of the Metabolic Network in Oenococcus oeni to Assess Wine Malolactic Fermentation

A motion capture protocol for the kinematic analysis of transfemoral and transtibial sprinters

Computational physiological modeling for lung-specific ventilation and perfusion management in ex vivo lung perfusion

Understanding the Role of Endothelial Glycocalyx in Mechanotransduction via Computational Simulation: A Mini Review

Mapping CAR T-Cell Design Space Using Agent-Based Models

Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine

In Silico and In Vivo: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model

BCNNM: A Framework for in silico Neural Tissue Development Modeling

DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications?

In silico Models of Alcohol Dependence and Treatment

A Middle-Out Modeling Strategy to Extend a Colon Cancer Logical Model Improves Drug Synergy Predictions in Epithelial-Derived Cancer Cell Lines

Evaluating the combined efficacy of Telisotuzumab Vedotin and artificial intelligence in the treatment of non-squamous non-small cell lung cancer: a narrative review focusing on pharmaceutical and technical insights

Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes