Introspection | List of Frontiers open access articles

Original Research

Published on 07 Nov 2025

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

in Molecular Diagnostics and Therapeutics

XiaoYu Luo
GuiPing Xie
QianYing Tan
YaoHui Wang
HaiDan Wang
Jing Zhai

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1683806

222 views

Clinical Trial

Published on 07 Nov 2025

Evaluation of the pharmacokinetics, pharmacodynamics, and liver ultrasound imaging characteristics of a novel perfluoropropane microbubble in Chinese volunteers

in Drug Metabolism and Transport

Pengfei Li
Ping Du
Zhixia Zhao
Fei Jia
Weiyue Yu
Peng Qu
Jiangfan Li
Xuhong Wang
Lihong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704972

124 views

Review

Published on 07 Nov 2025

Computational-aided drug design strategies for drug discovery and development against oral diseases

in Experimental Pharmacology and Drug Discovery

Tong Wu
Wentao Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678652

439 views

Review

Published on 07 Nov 2025

DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery

in Experimental Pharmacology and Drug Discovery

Yingli Yang
Yao Yao
Xiaoyu Cai
Yaqi Tao
Zhengbing Zhuge
Jianhong Zhou
Caihong Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688305

180 views

Original Research

Published on 07 Nov 2025

The mediating role of rumination between fear of disease progression and sleep disturbance in melanoma patients: a dual-perspective analysis based on person-centered and variable-centered approaches

in Public Mental Health

Qingjiang Huang
Fengwen Yue
Weitian Shi
Ying Lei
Ting Jiang

Frontiers in Public Health

doi 10.3389/fpubh.2025.1710386

156 views

Original Research

Published on 07 Nov 2025

Impact of biologic therapy on blood cell indices and exacerbation risk in severe asthma: predictive value of the neutrophil-to-eosinophil ratio

in Mechanisms in Allergy

Mona Al-Ahmad
Asmaa Ali
Wafaa Talat

Frontiers in Allergy

doi 10.3389/falgy.2025.1691886

355 views

Original Research

Published on 07 Nov 2025

Association of co-occurrence of gastrointestinal, sleep, and affective symptoms with Helicobacter pylori infection: a monocentric cross-sectional study in China

in Gut Endocrinology

ZhiHai Zhang
HongFei Ke
XiaoYan ShangGuan
NengJiang Zhao
Xin Hu
Bo Li
MiaoNa Cai
MeiQi Chen
JiaHao Liu
JieLong Wu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1675866

218 views

Case Report

Published on 07 Nov 2025

Resistance to imatinib in a ETV6::PDGFRB rearranged myeloid/lymphoid neoplasm with high-risk mutations: a case report

in Hematologic Malignancies

Lucia Cavelier
Leonie Saft
Birgitta Sander
Stefan Deneberg

Frontiers in Oncology

doi 10.3389/fonc.2025.1611747

313 views

Case Report

Published on 07 Nov 2025

Rifampicin-induced challenges in managing endocrine hypertension and primary aldosteronism: a case report and literature review

in Cardiovascular and Smooth Muscle Pharmacology

Xiaoxiao Song
Minyue Jia
Hanxiao Yu
Zhichao Dong
Kai Cheok
Xin Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678430

134 views

Original Research

Published on 07 Nov 2025

A randomized controlled trial of Shengji ointment combined with bromelain in promoting healing of tendon-exposed diabetic foot wounds: integrated 16S rDNA sequencing and metabolomics analysis

in Ethnopharmacology

Xu Sun
Jielin Song
Junchao Sun
Zhaohui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666278

427 views

Brief Research Report

Published on 07 Nov 2025

Salivary oxidative stress persists in inflammatory bowel disease regardless of biological treatment response

in Gastrointestinal and Hepatic Pharmacology

Elisabetta Bigagli
Tommaso Innocenti
Gabriele Dragoni
Francesco Pindozzi
Andrea Galli
Maura Lodovici
Cristina Luceri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699252

341 views

Original Research

Published on 07 Nov 2025

Establishment and validation of a prognostic risk model based on ADME-related genes in breast cancer

in Breast Cancer

Yang Yang
Lei Yan
Yang Feng
Yuling Liu
Guangmin Shi
Jiqing Hao

Frontiers in Oncology

doi 10.3389/fonc.2025.1568379

128 views

Original Research

Published on 07 Nov 2025

Effect of six weeks of blood flow restriction combined with Tabata training on anaerobic capacity in male badminton players

in Exercise Physiology

Yuancheng Xia
Xin Zheng
Kaixiang Zhou
Leyi Jiang
Bojun Song
Shuxian Xu
Zhangyuting Shang
Jin Dai

Frontiers in Physiology

doi 10.3389/fphys.2025.1656050

395 views

Brief Research Report

Published on 07 Nov 2025

Mindfulness training combined with cold water immersion effects on mood and perception of executive functioning in middle-aged and older adults: a pilot study

in Aging and Public Health

Ambra Gentile
Sara Vivirito
Musa Kirkar
Konstantinos Paschos
Luka Tuđan
Jakub Kulhánek
Pelin Öztürk
Marianna Alesi

Frontiers in Public Health

doi 10.3389/fpubh.2025.1693026

Original Research

Published on 07 Nov 2025

Impact of early vs. delayed intravenous magnesium sulfate on clinical outcomes in pediatric severe asthma: a retrospective cohort study

in Pediatric Emergency Medicine

Mohammid Alzain
Sajjad Alkhadem
Rafa Alotbi
Ibrahim Alammari
Norah Aljabri
Reem Almijlad
Shahd Abureesh
Hadeel Alharbi
Rawan Alrashed
Yara Algoraini

Frontiers in Disaster and Emergency Medicine

doi 10.3389/femer.2025.1689282

302 views

Original Research

Published on 07 Nov 2025

Clean energy and the fragile supply chain: lessons from U.S.-China trade tensions and energy shocks

in Environmental Economics and Management

Kamel Si Mohammed
Magdalena Radulescu
Said khalfa Brika
Luigi Popescu
Marinela Barbulescu

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1660197

387 views

Articles

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

Evaluation of the pharmacokinetics, pharmacodynamics, and liver ultrasound imaging characteristics of a novel perfluoropropane microbubble in Chinese volunteers

Computational-aided drug design strategies for drug discovery and development against oral diseases

DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery

The mediating role of rumination between fear of disease progression and sleep disturbance in melanoma patients: a dual-perspective analysis based on person-centered and variable-centered approaches

Impact of biologic therapy on blood cell indices and exacerbation risk in severe asthma: predictive value of the neutrophil-to-eosinophil ratio

Association of co-occurrence of gastrointestinal, sleep, and affective symptoms with Helicobacter pylori infection: a monocentric cross-sectional study in China

Resistance to imatinib in a ETV6::PDGFRB rearranged myeloid/lymphoid neoplasm with high-risk mutations: a case report

Rifampicin-induced challenges in managing endocrine hypertension and primary aldosteronism: a case report and literature review

A randomized controlled trial of Shengji ointment combined with bromelain in promoting healing of tendon-exposed diabetic foot wounds: integrated 16S rDNA sequencing and metabolomics analysis

Salivary oxidative stress persists in inflammatory bowel disease regardless of biological treatment response

Establishment and validation of a prognostic risk model based on ADME-related genes in breast cancer

Effect of six weeks of blood flow restriction combined with Tabata training on anaerobic capacity in male badminton players

Mindfulness training combined with cold water immersion effects on mood and perception of executive functioning in middle-aged and older adults: a pilot study

Impact of early vs. delayed intravenous magnesium sulfate on clinical outcomes in pediatric severe asthma: a retrospective cohort study

Clean energy and the fragile supply chain: lessons from U.S.-China trade tensions and energy shocks