Osteoarthritis Pathogenesis | List of Frontiers open access articles

Mini Review

Published on 25 Nov 2025

Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications

in Systems Immunology

Kun Zhang
Zheng Wang
Jiaqi He
Liuru Lu
Wenshu Wang
Aiwei Yang
Huayi Xie
Linhui Huang
Yuying Huang
Ke Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637731

3,850 views
9 citations

Original Research

Published on 17 May 2023

Bioinformatic analysis reveals potential relationship between chondrocyte senescence and protein glycosylation in osteoarthritis pathogenesis

in Bone Research

Makoto Yoshimoto
Koki Sadamori
Kazuya Tokumura
Yuki Tanaka
Kazuya Fukasawa
Eiichi Hinoi

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1153689

8,835 views
10 citations

Opinion

Published on 29 Sep 2025

Nutritional metabolic dysregulation in T2DM as a catalyst for osteoarthritis pathogenesis

in Nutrition and Metabolism

Chengyan Wang
Xiaodong Yu
Xianqiu Zeng
Ming Li
Wenxiao Yang
Shu Zhou

Frontiers in Nutrition

doi 10.3389/fnut.2025.1676056

3,049 views

Original Research

Published on 16 Apr 2021

RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7

in Stem Cell Research

Jin Cheng
Xiaoning Duan
Xin Fu
Yanfang Jiang
Peng Yang
Chenxi Cao
Qi Li
Jiying Zhang
Xiaoqing Hu
Xin Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.638382

6,695 views
33 citations

Original Research

Published on 09 May 2023

A cytokine-induced spheroid-based in vitro model for studying osteoarthritis pathogenesis

in Tissue Engineering and Regenerative Medicine

Annachiara Scalzone
Giorgia Cerqueni
Xiao Nong Wang
Kenny Dalgarno
Monica Mattioli-Belmonte
Ana M. Ferreira-Duarte
Piergiorgio Gentile

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1167623

4,460 views
12 citations

Original Research

Published on 12 Feb 2024

Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care

in Musculoskeletal Pain

Malvika Gulati
Gretchen Brewer
Andrew Judge
Donna Kennedy
Tonia L. Vincent
Fiona E. Watt

Frontiers in Pain Research

doi 10.3389/fpain.2024.1331187

3,656 views
3 citations

Review

Published on 09 Jun 2023

Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression

in Cancer Immunity and Immunotherapy

Chenxiao Zheng
Jiayi Chen
Yurui Wu
Xiaochao Wang
Yongan Lin
Lilu Shu
Wenjun Liu
Peter Wang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1217466

7,985 views
21 citations

Review

Published on 26 Nov 2020

Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases

in Stem Cell Research

Sina Stucker
Junyu Chen
Fiona E. Watt
Anjali P. Kusumbe

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2020.602269

16,943 views
65 citations

Review

Published on 12 Nov 2025

The “gut microbiota-ferroptosis axis”: a hypothesis for osteoarthritis pathogenesis and therapeutic implications

in Systems Microbiology

Tao Wang
Yuanze Xu
Haorui Zha
Lianguo Wu

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1685962

3,443 views
3 citations

Original Research

Published on 06 Jan 2026

Crotonylation-related gene GCDH promotes osteoarthritis pathogenesis through flavin adenine dinucleotide signaling: mechanism exploration and experimental validation

in Nutrition and Metabolism

Jingkai Di
Zijian Guo
Yijing Di
Luyi Zhang
Yingda Qin
Feida Wang
Chuan Xiang

Frontiers in Nutrition

doi 10.3389/fnut.2025.1646005

1,528 views

Review

Accepted on 04 May 2026

From Mechanical Triggering to Metabolic-Inflammatory Driving: A New Paradigm of Knee Osteoarthritis Pathogenesis

in Inflammation

ManLi Yan
Xin Zhang
Hao Liu
Qingyang Kang
Jianjiang Li
Baoqing Zhang
Lin Dingkun
Xiang Li

Frontiers in Immunology

105 views

Original Research

Published on 19 Nov 2021

CircPan3 Promotes the Ghrelin System and Chondrocyte Autophagy by Sponging miR-667-5p During Rat Osteoarthritis Pathogenesis

in Molecular and Cellular Pathology

Jing Zeng
Zhenzhen Zhang
Qing Liao
Qijin Lu
Jiemei Liu
Lixia Yuan
Gang Liu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.719898

4,757 views
16 citations

Articles

Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications

Bioinformatic analysis reveals potential relationship between chondrocyte senescence and protein glycosylation in osteoarthritis pathogenesis

Nutritional metabolic dysregulation in T2DM as a catalyst for osteoarthritis pathogenesis

RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7

A cytokine-induced spheroid-based in vitro model for studying osteoarthritis pathogenesis

Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care

Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression

Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases

The “gut microbiota-ferroptosis axis”: a hypothesis for osteoarthritis pathogenesis and therapeutic implications

Crotonylation-related gene GCDH promotes osteoarthritis pathogenesis through flavin adenine dinucleotide signaling: mechanism exploration and experimental validation

From Mechanical Triggering to Metabolic-Inflammatory Driving: A New Paradigm of Knee Osteoarthritis Pathogenesis

CircPan3 Promotes the Ghrelin System and Chondrocyte Autophagy by Sponging miR-667-5p During Rat Osteoarthritis Pathogenesis