Penalized Spline | List of Frontiers open access articles

Original Research

Published on 08 Oct 2025

Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis

in Cardiovascular and Smooth Muscle Pharmacology

Ayman M. Mahmoud
Sulaiman M. Alnasser
Omnia A. M. Abd El-Ghafar
Reem S. Alruhaimi
Hanan S. Althagafy
Ahmed M. Atwa
Emad H. M. Hassanein

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678921

1,165 views

Original Research

Published on 08 Oct 2025

Network topological reorganization mechanisms of primary visual cortex under multimodal stimulation

in Neuromorphic Engineering

Zhen Li
Zhiyong Peng
LiHua He
Xuan Zhu
Dewen Hu
Ming Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1678035

1,174 views

Mini Review

Published on 08 Oct 2025

The pathophysiological mechanisms of immunosenescence in coronary artery disease

in Cell Death and Survival

Hengjie Bie
Zhengxian Tao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1686947

634 views

Correction

Published on 08 Oct 2025

Correction: Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

in Oral Infections and Microbes

Peiling Hu
Ping Long
Ruotong Li
Xiaorong Lan
Yuanpei He
Guangwen Li
Shiting Li

Frontiers in Oral Health

doi 10.3389/froh.2025.1687229

198 views

Original Research

Published on 08 Oct 2025

Exploring the association between grade point average and work engagement: insights from a cross-sectional study of medical students

in Healthcare Professions Education

Runzhi Huang
Jiajie Zhou
Yang Chen
Wei Zhang
Min Lin
Meiqiong Gong
Bingnan Lu
Minghao Jin
Yuntao Yao
Yuwei Lu

Frontiers in Medicine

doi 10.3389/fmed.2025.1536482

302 views

Original Research

Published on 08 Oct 2025

Impact of different production systems on the slaughter performance and meat quality of gayal (Bos frontalis)

in Animal Nutrition and Metabolism

Li Zhi
Qing Li
Zibei Wang
Meng Zhang
Shichun He
Hao Zhang
Sifan Dai
Lijuan Zhang
Shusheng Zhao
Feng Jiang

Frontiers in Veterinary Science

doi 10.3389/fvets.2025.1538622

589 views

Original Research

Published on 08 Oct 2025

Family environment and frequency of vegetable consumption among children aged 6 to 12 years

in Nutrition and Sustainable Diets

Laura Raggio
Guadalupe Herrera
Adriana Gámbaro

Frontiers in Nutrition

doi 10.3389/fnut.2025.1552240

698 views

Case Report

Published on 08 Oct 2025

Case Report: Pathological diagnosis of left upper lobe nodules: two cases of composite small cell lung cancer and literature review

in Thoracic Oncology

Jishen Zhang
Defeng Jin
Yutao Wei

Frontiers in Oncology

doi 10.3389/fonc.2025.1629307

492 views

Original Research

Published on 08 Oct 2025

Development trajectory of humanistic care and occupational calling in nursing students during internship: a multi-center longitudinal study

in Healthcare Professions Education

Maoxia Su
Qian Deng
Yi Hu
Yanni Chen

Frontiers in Medicine

doi 10.3389/fmed.2025.1632335

552 views

Original Research

Published on 08 Oct 2025

Construction of community home-based older adult care service model based on modular design concept

in Aging and Public Health

Xiaohua Zhou
Lina Chen
Xu Lou
Ying Li
Bobo Han

Frontiers in Public Health

doi 10.3389/fpubh.2025.1672918

677 views

Original Research

Published on 08 Oct 2025

Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus

in Cancer Immunity and Immunotherapy

Xiaolei Yin
Xiaopeng Li
Lili Mi
Jiaojiao Hou
Fei Yin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672587

747 views

Case Report

Published on 08 Oct 2025

Case Report: A patient with lynch syndrome with vaginal endometriosis-associated malignancy and synchronous colonic tubulovillous adenoma

in Obstetrics and Gynecology

Ting Kuang
Xiaoping Liu
Qi Li
Meiyuan Huang
Ziqian Tang
Xidie Li
Jinjin Wang
Huan Chen

Frontiers in Medicine

doi 10.3389/fmed.2025.1672641

141 views

Review

Published on 08 Oct 2025

Research progress on the role of microbiota in the pathogenesis of gallstone disease

in Infectious Agents and Disease

Yuntian Liu
Bihui Yao
Xiaoqin Yang
Qi Sun
Xusheng Yang
Lu Liang

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1672767

587 views

Original Research

Published on 08 Oct 2025

Exploring multimodal collaborative storytelling with Pepper: a preliminary study with zero-shot LLMs

in Human-Robot Interaction

Unai Zabala
Juan Echevarria
Igor Rodriguez
Elena Lazkano

Frontiers in Robotics and AI

doi 10.3389/frobt.2025.1662819

525 views

Original Research

Published on 08 Oct 2025

Diffusion tensor imaging along the perivascular space may reveal potential pathological mechanisms underlying disease progression in primary open-angle glaucoma patients

in Applied Neuroimaging

Yilei Chen
Shuyu Xiao
Lvyu Yan
Zhigang Gong
Yanwen Huang
Wenli Tan
Ying Yu

Frontiers in Neurology

doi 10.3389/fneur.2025.1659200

597 views

Original Research

Published on 08 Oct 2025

An implantable, intracerebral osmotic pump for convection-enhanced drug delivery in glioblastoma multiforme

in Neuro-Oncology and Neurosurgical Oncology

Reed Berlet
Azur Azapagic
Neilank K. Jha
Daniil Aksenov
Jade Bookwalter
Ata Ullah
George Bobustuc
John Lee
Himanshu Sant
John McDaid

Frontiers in Oncology

doi 10.3389/fonc.2025.1676691

942 views

Articles

Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis

Network topological reorganization mechanisms of primary visual cortex under multimodal stimulation

The pathophysiological mechanisms of immunosenescence in coronary artery disease

Correction: Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

Exploring the association between grade point average and work engagement: insights from a cross-sectional study of medical students

Impact of different production systems on the slaughter performance and meat quality of gayal (Bos frontalis)

Family environment and frequency of vegetable consumption among children aged 6 to 12 years

Case Report: Pathological diagnosis of left upper lobe nodules: two cases of composite small cell lung cancer and literature review

Development trajectory of humanistic care and occupational calling in nursing students during internship: a multi-center longitudinal study

Construction of community home-based older adult care service model based on modular design concept

Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus

Case Report: A patient with lynch syndrome with vaginal endometriosis-associated malignancy and synchronous colonic tubulovillous adenoma

Research progress on the role of microbiota in the pathogenesis of gallstone disease

Exploring multimodal collaborative storytelling with Pepper: a preliminary study with zero-shot LLMs

Diffusion tensor imaging along the perivascular space may reveal potential pathological mechanisms underlying disease progression in primary open-angle glaucoma patients

An implantable, intracerebral osmotic pump for convection-enhanced drug delivery in glioblastoma multiforme

Family environment and frequency of vegetable consumption among children aged 6 to 12 years