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CORRECTION article

Front. Oral Health, 08 October 2025

Sec. Oral Infections and Microbes

Volume 6 - 2025 | https://doi.org/10.3389/froh.2025.1687229

Correction: Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

This article is a correction to:

  1. Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

    1. Read original article
Peiling Hu,&#x;Peiling Hu1,†Ping Long,&#x;Ping Long1,†Ruotong Li,&#x;Ruotong Li1,†Xiaorong Lan,Xiaorong Lan1,2Yuanpei HeYuanpei He1Guangwen Li, Guangwen Li1,2*Shiting Li Shiting Li1*
  • 1School of Stomatology, Southwest Medical University, Lu Zhou, China
  • 2Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, China

A Correction on

Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

By Hu P, Long P, Li R, Lan X, He Y, Li G and Li S. Front Oral Health. 2024;5:1496819. doi: 10.3389/froh.2024.1496819

Error in figure/table

Wrong content

There was a mistake in Figure 1 as published. [1. Panel 1A inadvertently displayed an incorrect tooth specimen due to a clerical error during image compilation. We have replaced it with the validated sample, consistent with original experimental records. 2. Panel 1D was misclassified as a distinct diagnostic category, duplicating the irreversible pulpitis cohort shown in Panels 1E and 1F. This panel must be deleted to resolve grouping redundancy]. The corrected Figure 1 appears below.

Figure 1
Histological and immunofluorescence images comparing five dental conditions: healthy teeth, superficial/intermediate caries, deep caries, and irreversible pulpitis. The left panel shows H&E stained sections with structural details indicated by blue arrows. The right panel displays Cx43 expression and DAPI staining, with merged images highlighting differences in expression levels across conditions. A bar graph (F) shows relative fluorescence expression intensity of Cx43, significantly increasing from healthy teeth to irreversible pulpitis with statistical annotations.

Figure 1. The expression profile of Cx43 in human third molars (n = 3/group). Cx43 (red arrow) immunofluorescence staining and quantitative analysis in infected teeth and healthy controls. Blue arrows: inflammatory cells; a/od: odontoblast layer; b: cell-rich zone; c: pulp proper; d: dentin; P: dental pulp; (A) Healthy teeth; (B) Superficial/Intermediate caries; (C) Deep caries; (D,E) Irreversible pulpitis; scale bar: 20 µm; (F) Quantitative fluorescence analysis of Cx43 in various groups of dental pulp. **P < 0.01, ****P < 0.0001.

Figure/table caption

There was a mistake in the caption of Figure 1 as published. [The published caption incorrectly described Panel 1A due to inadvertent specimen misidentification and erroneously included Panel 1D as a distinct diagnostic category, duplicating the irreversible pulpitis cohort. These inaccuracies necessitated panel replacement (1A), deletion (1D), re-sequencing of subsequent panels, and comprehensive legend revision]. The corrected caption of Figure 1 appears below.

“[Figure 1. The expression profile of Cx43 in human third molars (n = 3/group). Cx43 (red arrow) immunofluorescence staining and quantitative analysis in infected teeth and healthy controls. Blue arrows: inflammatory cells; a/od: odontoblast layer; b: cell-rich zone; c: pulp proper; d: dentin; P: dental pulp; (A) Healthy teeth; (B) Superficial/Intermediate caries; (C) Deep caries; (D,E) Irreversible pulpitis; scale bar: 20 µm; (F) Quantitative fluorescence analysis of Cx43 in various groups of dental pulp. **P < 0.01, ****P < 0.0001.]”

The original version of this article has been updated.

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Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: deep caries, connexin43 hemichannel, inflammatory response, dental pulp cells, DAMPs

Citation: Hu P, Long P, Li R, Lan X, He Y, Li G and Li S (2025) Correction: Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1. Front. Oral Health 6:1687229. doi: 10.3389/froh.2025.1687229

Received: 17 August 2025; Accepted: 26 September 2025;
Published: 8 October 2025.

Edited by:

Georgios N. Belibasakis, Karolinska Institutet (KI), Sweden

Reviewed by:

Juan Saez, Universidad de Valparaiso, Chile

Copyright: © 2025 Hu, Long, Li, Lan, He, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Shiting Li, dGluZ3RpbmdoaWdoQHNpbmEuY29t; Guangwen Li, bGlndWFuZ3dlbkBzd211LmVkdS5jbg==

†These authors have contributed equally to this work and share first authorship

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.