Penalized Spline | List of Frontiers open access articles

Original Research

Published on 03 Sep 2025

Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

in Veterinary Pharmacology and Toxicology

Silvana Alvariza
Manuel Ibarra
Natalia Guevara
Cecilia Maldonado
Marta Vázquez
Gimena Feijoó
Gonzalo Suárez

Frontiers in Veterinary Science

doi 10.3389/fvets.2025.1644003

213 views

Original Research

Published on 03 Sep 2025

Development and validation of multiparameter prognostic nomogram combining neutrophil-to-lymphocyte ratio, tumor burden, and nutritional status for predicting postoperative outcome in elderly gastric cancer patients

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Dongyuan Liu
Yan Jiang
Min Gao

Frontiers in Oncology

doi 10.3389/fonc.2025.1620443

155 views

Original Research

Published on 03 Sep 2025

Research on the construction of an evaluation index system of teachers’ online learning power based on online professional learning communities

in Educational Psychology

Lei Xiang
Liumei Yu

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1586319

203 views

Original Research

Published on 03 Sep 2025

Nodal Na+ and Ca2+ flux dynamics in cortical myelinated axons

in Cellular Neurophysiology

Oron Kotler
Kenichi Miyazaki
Yana Khrapunsky
William N. Ross
Ilya A. Fleidervish

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1662730

272 views

Original Research

Published on 03 Sep 2025

Safety, tolerability, and pharmacokinetics of faldaprevir after single increasing doses in healthy subjects

in Drug Metabolism and Transport

Chan-Loi Yong
Regina Sennewald
Gerhard Nehmiz
Anne-Marie Quinson
Fenglei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622249

258 views

Original Research

Published on 03 Sep 2025

Structural valve deterioration is primarily caused by cyclic fatigue but not immune rejection

in Alloimmunity and Transplantation

Alexander E. Kostyunin
Tatiana V. Glushkova
Evgeny A. Ovcharenko
Pavel S. Onischenko
Kirill Yu. Klyshnikov
Tatiana N. Akentieva
Leo A. Bogdanov
Vladislav A. Koshelev
Alexander N. Stasev
Anton A. Khromov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652294

263 views

Original Research

Published on 03 Sep 2025

Multi-omics integration uncovers key transcriptional regulators in triple-negative breast cancer spatial heterogeneity

in Computational Genomics

Ning Zhang
Ye Zhang
Rui-Fei Yang
Hai-Qing Chu
Abdur Rehman
Lu-Yu Yang
Ya-Yu Li
Xin Zhou
Shou-Ping Gong
Hui-Ling Cao

Frontiers in Genetics

doi 10.3389/fgene.2025.1614254

337 views

Systematic Review

Published on 03 Sep 2025

Prognostic biomarkers for predicting decompensation in alcoholic and non-alcoholic patients with compensated cirrhosis: a systematic review and meta-analysis

in Gastroenterology

Kristina Baktikulova
Saulesh Kurmangaliyeva
Kairat Kurmangaliyev
Konstantin Tissin
Nadiar M. Mussin
Amin Tamadon

Frontiers in Medicine

doi 10.3389/fmed.2025.1650124

205 views

Original Research

Published on 03 Sep 2025

Associations between daily dietary carbohydrate intake and TIR in adults with type 1 diabetes

in Clinical Nutrition

Yunying Cai
Xi Li
Xin Xiong
Lun Zhang
Jianfeng He
Heng Su

Frontiers in Nutrition

doi 10.3389/fnut.2025.1638849

247 views

Case Report

Published on 03 Sep 2025

Peripartum cardiomyopathy in a 28-year-old patient—case report

in Heart Failure and Transplantation

Katarzyna Hajduk
Aleksandra Gil
Wojciech Papis
Gabriela Skórska
Joanna Śliwka
Szymon Pawlak
Tomasz Hrapkowicz

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1666816

157 views

Editorial

Published on 03 Sep 2025

Editorial: Towards precision oncology: assessing the role of radiomics and artificial intelligence

in Artificial Intelligence in Radiology

Salvatore Claudio Fanni
Damiano Caruso
Lorenzo Faggioni
Emanuele Neri
Dania Cioni

Frontiers in Radiology

doi 10.3389/fradi.2025.1676229

299 views

Editorial

Published on 03 Sep 2025

Editorial: Reviews in gut-brain axis: stress, dysregulation in gut-brain axis function and stress related disorders

in Gut-Brain Axis

Zuleide Maria Ignácio
Jonathan B. Clayton
Margarete Dulce Bagatini
Avinash Veerappa

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1665282

591 views

Opinion

Published on 03 Sep 2025

3D human epithelial models: a promising platform for studying Candida infections and novel antifungal therapeutic options

in Antibiotic Resistance and New Antimicrobial drugs

Cristina Schöpf
Florentine Marx

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1680261

285 views

Original Research

Published on 03 Sep 2025

Investigation of the genome, taxonomy, and distribution of pigeon gammacoronavirus: insights into its relationships with other avian gammacoronaviruses

in Virology

Sumei Tan
Xiu Wang
Qingye Zhuang
Huanyu Gong
Ruixu Chen
Jiming Chen
Dahai Liu
Ming Liao

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1647728

163 views

Review

Published on 03 Sep 2025

Stem/progenitor cell-based therapy for Duchenne muscular dystrophy

in Stem Cell Research

Tsukasa Tominari
Chaitra Sathyaprakash
Yoshitsugu Aoki

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1640275

578 views

Original Research

Published on 03 Sep 2025

Evaluating large language models in pediatric fever management: a two-layer study

in Health Communications and Behavior Change

Guijun Yang
Hejun Jiang
Shuhua Yuan
Mingyu Tang
Jing Zhang
Jilei Lin
Jiande Chen
Jiajun Yuan
Liebin Zhao
Yong Yin

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1610671

341 views

Articles

Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

Development and validation of multiparameter prognostic nomogram combining neutrophil-to-lymphocyte ratio, tumor burden, and nutritional status for predicting postoperative outcome in elderly gastric cancer patients

Research on the construction of an evaluation index system of teachers’ online learning power based on online professional learning communities

Nodal Na+ and Ca2+ flux dynamics in cortical myelinated axons

Safety, tolerability, and pharmacokinetics of faldaprevir after single increasing doses in healthy subjects

Structural valve deterioration is primarily caused by cyclic fatigue but not immune rejection

Multi-omics integration uncovers key transcriptional regulators in triple-negative breast cancer spatial heterogeneity

Prognostic biomarkers for predicting decompensation in alcoholic and non-alcoholic patients with compensated cirrhosis: a systematic review and meta-analysis

Associations between daily dietary carbohydrate intake and TIR in adults with type 1 diabetes

Peripartum cardiomyopathy in a 28-year-old patient—case report

Editorial: Towards precision oncology: assessing the role of radiomics and artificial intelligence

Editorial: Reviews in gut-brain axis: stress, dysregulation in gut-brain axis function and stress related disorders

3D human epithelial models: a promising platform for studying Candida infections and novel antifungal therapeutic options

Investigation of the genome, taxonomy, and distribution of pigeon gammacoronavirus: insights into its relationships with other avian gammacoronaviruses

Stem/progenitor cell-based therapy for Duchenne muscular dystrophy

Evaluating large language models in pediatric fever management: a two-layer study