Southern Brazil | List of Frontiers open access articles

Original Research

Published on 09 Oct 2025

Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models

in Cancer Immunity and Immunotherapy

Mulu Z. Tesfay
Aleksandra Cios
Khandoker Usran Ferdous
Randal S. Shelton
Bahaa Mustafa
Camila C. Simoes
Murat Gokden
Isabelle R. Miousse
Kimberly J. Krager
Marjan Boerma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679665

631 views

Original Research

Published on 09 Oct 2025

Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound

in Genitourinary Oncology

You Zhou
Mingyou Liu
Jiguang Zhou
Hanzong Lin
Jinxin Lan
Yusheng Xu
Xiao Yang
Ming Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1644411

717 views

Original Research

Published on 09 Oct 2025

Zoning of urban territorial spaces: evaluating socio-economic-ecological low-carbon development efficiency in Xuzhou, China

in Social-Ecological Urban Systems

Pin Liu
Xiang Ji
Dong Wang
Deping Jiang
Xiaochun Hong

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1636744

590 views

Original Research

Published on 09 Oct 2025

Predictors of therapy switching to high-efficacy disease-modifying therapies in patients with multiple sclerosis: a single center, retrospective, observational study

in Multiple Sclerosis and Neuroimmunology

Gytis Makarevičius
Rasa Kizlaitienė
Gintaras Kaubrys
Nataša Giedraitienė

Frontiers in Neurology

doi 10.3389/fneur.2025.1635618

865 views

Review

Published on 09 Oct 2025

Inverse geo-electromagnetic modeling: a systematic review and bibliometric assessment

in Solid Earth Geophysics

Octavio Castillo-Reyes
José Luis Jiménez-Andrade
Rahul Dehiya
Ursula Iturrarán-Viveros

Frontiers in Earth Science

doi 10.3389/feart.2025.1645896

641 views

Original Research

Published on 09 Oct 2025

Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in Escherichia coli

in Synthetic Biology

Shimiao Chen
Bin Shan
Yican Luo
Ganhui Mo
Usman Rasheed
Lilan Lv
Xinyu Yang
Qinyu Lu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1643833

633 views

Original Research

Published on 09 Oct 2025

Ferroptosis’s Master Switch GPX4 emerges as universal biomarker for precision immunotherapy: a pan-cancer study with in vitro experiments validation

in Cancer Immunity and Immunotherapy

Xiao Li
Min Zhu
Ruihua Dong

Frontiers in Oncology

doi 10.3389/fonc.2025.1643235

537 views

Original Research

Published on 09 Oct 2025

Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential

in Microbiotechnology

Konstantinos Gaitanis
Eirini Gkogkou
Paris Laskaris
Nikolaοs Tsafantakis
Despoina D. Gianniou
Stavroula I. Kaili
Georgia C. Ntroumpogianni
Aikaterini Theodosopoulou
Nikola Milic
Dimitris G. Hatzinikolaou

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1649460

1,149 views

Original Research

Published on 09 Oct 2025

Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials

in Experimental Pharmacology and Drug Discovery

Virginie Piffaut
Romain De Dormael
Jean-Philippe Belaidi
Laudine Bertrand
Thierry Passeron
Françoise Bernerd
Claire Marionnet

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651068

625 views

Original Research

Published on 09 Oct 2025

Identification of the wbtF gene as a cytotoxicity-associated factor in Francisella novicida infection

in Bacteria and Host

Dhandy Koesoemo Wardhana
Takashi Shimizu
Kenta Watanabe
Akihiko Uda
Masahisa Watarai

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1647652

510 views

Original Research

Published on 09 Oct 2025

Hydro- and sediment dynamics in a cold-water coral reef: insights from a 3D numerical model

in Coral Reef Research

Gerhard Bartzke
Dierk Hebbeln
Katrin Huhn

Frontiers in Marine Science

doi 10.3389/fmars.2025.1654625

517 views

Original Research

Published on 09 Oct 2025

Indole-3-carboxamide alleviates LPS-induced endometritis through suppressing ferroptosis and inflammation via regulating Aryl hydrocarbon receptor

in Veterinary and Zoonotic Infection

Feng Chen
Rujin Cheng
Xiangyang Chen
Zhiheng Guo

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1649801

490 views

Original Research

Published on 09 Oct 2025

Targeting macrophage-myofibroblast transition with Caulis spatholobi to attenuate renal interstitial fibrosis: integrated UHPLC-Q-Exactive Orbitrap-MS, network pharmacology, and experimental validation

in Translational Pharmacology

Ziyi Song
Yunlong Zhang
Chao Yang
Kexin Ren
Yijing Cheng
Zhujiang Zhang
Tianjiao Ren
Yixuan Chen
Xue Li
Yan Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649902

503 views

Original Research

Published on 09 Oct 2025

Determinants of healthcare expenditures: evidence from Türkiye’s healthcare system

in Health Economics

Hülya Diğer
Kübranur Çebi Karaaslan
Ahmet Köstekçi
Abdullah Göv

Frontiers in Public Health

doi 10.3389/fpubh.2025.1632883

1,037 views

Original Research

Published on 09 Oct 2025

Investigating the potential impacts and interactive effects of climate warming and multi-gear fishing on the Eastern Ionian Sea ecosystem using EwE and ecological indicators

in Marine Fisheries, Aquaculture and Living Resources

Georgia Papantoniou
Vasiliki Sgardeli
Vassiliki Vassilopoulou
Konstantinos Tsagarakis

Frontiers in Marine Science

doi 10.3389/fmars.2025.1621603

1,040 views

Case Report

Published on 09 Oct 2025

Case Report: Talaromyces marneffei infections associated with pharyngeal and laryngeal injuries in three children with aberrant innate immunity: a case series

in Pediatric Pulmonology

Changhao Zhang
Gen Lu
Xuehua Xu
Huifeng Fan

Frontiers in Pediatrics

doi 10.3389/fped.2025.1615943

349 views

Articles

Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models

Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound

Zoning of urban territorial spaces: evaluating socio-economic-ecological low-carbon development efficiency in Xuzhou, China

Predictors of therapy switching to high-efficacy disease-modifying therapies in patients with multiple sclerosis: a single center, retrospective, observational study

Inverse geo-electromagnetic modeling: a systematic review and bibliometric assessment

Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in Escherichia coli

Ferroptosis’s Master Switch GPX4 emerges as universal biomarker for precision immunotherapy: a pan-cancer study with in vitro experiments validation

Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential

Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials

Identification of the wbtF gene as a cytotoxicity-associated factor in Francisella novicida infection

Hydro- and sediment dynamics in a cold-water coral reef: insights from a 3D numerical model

Indole-3-carboxamide alleviates LPS-induced endometritis through suppressing ferroptosis and inflammation via regulating Aryl hydrocarbon receptor

Targeting macrophage-myofibroblast transition with Caulis spatholobi to attenuate renal interstitial fibrosis: integrated UHPLC-Q-Exactive Orbitrap-MS, network pharmacology, and experimental validation

Determinants of healthcare expenditures: evidence from Türkiye’s healthcare system

Investigating the potential impacts and interactive effects of climate warming and multi-gear fishing on the Eastern Ionian Sea ecosystem using EwE and ecological indicators

Case Report: Talaromyces marneffei infections associated with pharyngeal and laryngeal injuries in three children with aberrant innate immunity: a case series